在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TUBB1 Antibody, Biotin conjugated

  • 中文名稱:
    TUBB1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA867148LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TUBB1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Tubulin beta-1 chain protein (270-451AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻:
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
    3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
    4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
    5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
    6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
    7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
    8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
    9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
    11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
    12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
    13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
    14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
    15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255

    顯示更多

    收起更多

  • 相關疾病:
    Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Tubulin family
  • 組織特異性:
    Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
  • 數據庫鏈接:

    HGNC: 16257

    OMIM: 612901

    KEGG: hsa:81027

    STRING: 9606.ENSP00000217133

    UniGene: Hs.303023



主站蜘蛛池模板: 欧美成人片在线观看| 成人免费精品网站在线观看影片| 国产区精品一区二区不卡中文| 激情综合五月丁香亚洲| 国产精品二区一区二区aⅴ污介绍| 大帝a∨无码视频在线播放 | 国语自产拍精品香蕉在线播放| 亚洲gv永久无码天堂网| 欧洲专线一区二区三区| 在线观看老湿视频福利| 欧洲熟妇色 欧美| 成人无码潮喷在线观看| 永久免费观看美女裸体视频的网站| 欧洲熟妇色xxxx欧美老妇软件| 在线播放免费人成视频在线观看 | 中文字幕av无码专区第一页| 午夜影视免费| 最近免费中文字幕大全免费版视频| 国产精品一区二区久久乐下载| 国产suv精二区| 国产真实伦在线观看| 亚洲啪av永久无码精品放毛片| 亚洲处破女av日韩精品| 精品日产一卡二卡| 亚洲熟女综合色一区二区三区 | 狠狠色噜噜狠狠狠8888在| 无码大潮喷水在线观看| 亚洲欧美日韩精品久久| 无码人妻精品一区二| 国语对白做受xxxxx在| 久久国产免费直播| 免费国产黄网站在线观看动图| 无码精品国产一区二区三区免费| 精品高朝久久久久9999| 亚洲欧洲日本综合aⅴ在线 | 亚洲国产精品成人久久 | 亚洲国产成人乱码| 国产精品无码av片在线观看播| 国语高潮无遮挡无码免费看| 无码超乳爆乳中文字幕| 国产精品爆乳在线播放第一人称 |