在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. TUBB1 Monoclonal Antibody

TUBB1 Monoclonal Antibody

  • 中文名稱：
    TUBB1鼠單克隆抗體
  • 貨號：
    CSB-MA000278
  • 規格：
    ￥1090
  • 圖片：
    • Western blot analysis of Zebrafish skeletal muscle, diluted at 1:5000.
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA000278單克隆抗體是針對斑馬魚TUBB1靶點研發的科研專用試劑，適用于免疫印跡和酶聯免疫吸附實驗。TUBB1作為β-微管蛋白家族成員，在細胞骨架構成、有絲分裂調控及細胞形態維持中發揮關鍵作用，是研究細胞周期動態和細胞極性機制的重要分子標記物。該產品采用重組蛋白免疫技術制備，具備高親和力和特異性，經過嚴格驗證可精準識別斑馬魚模型中的TUBB1蛋白，為發育生物學、神經軸突導向研究和細胞遷移實驗提供可靠工具，尤其適用于胚胎發育階段的微管網絡可視化分析和基因功能驗證。通過優化抗體反應體系，可在斑馬魚組織裂解液中實現清晰的蛋白條帶檢測，滿足細胞骨架動態監測、基因敲除效果評估等基礎科研需求，為探索微管相關疾病機制提供有效研究手段。
  • Uniprot No.：
  • 基因名：
  • 別名：
    2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Zebrafish
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    8H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻：
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
    3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
    4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
    5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
    6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
    7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
    8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
    9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
    11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
    12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
    13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
    14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
    15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255

    顯示更多

    收起更多

  • 相關疾病：
    Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
  • 數據庫鏈接：

    HGNC: 16257

    OMIM: 612901

    KEGG: hsa:81027

    STRING: 9606.ENSP00000217133

    UniGene: Hs.303023



主站蜘蛛池模板： 国产午夜精品久久久久免费视| 国产强奷在线播放免费| 国产高潮流白浆视频| 夜夜高潮夜夜爽夜夜爱爱| 日日噜噜噜夜夜爽爽狠狠| 无码专区天天躁天天躁在线 | 五月激激激综合网亚洲| 99国产揄拍国产精品人妻| 精品人妻无码一区二区色欲产成人| 日韩成人一区二区三区在线观看| 午夜福利理论片高清在线| 先锋影音人妻啪啪va资源网站| 久久国产精品无码网站| 国产蜜臀av在线一区尤物| 蜜桃av无码免费看永久| 亚洲日韩国产精品无码av| 北条麻妃在线一区二区| 一本色道久久88综合日韩精品| 国产超碰无码最新上传| 久久综合九色综合欧洲98| 国产男女免费完整视频网页| 无码国产精品一区二区免费模式| 乱色欧美激惰| 免费看国产精品3a黄的视频| 好想被狂躁无码视频在线观看 | 狠狠躁天天躁无码中文字幕| 伊人久久无码中文字幕| 97人妻天天爽夜夜爽二区| 香蕉97超级碰碰碰免费公开| 国产偷窥熟女精品视频| 国产精品美女一区二区视频| 亚洲女教师丝祙在线播放| 日本高清色本在线www| 337p粉嫩大胆色噜噜噜| 丝袜老师办公室里做好紧好爽| 天堂在线最新版www中文| 成人免费毛片内射美女-百度| 美女国产毛片a区内射| 久久青青草原国产最新片完整| 亚洲一区二区三区中文字幕在线| 亚洲精品蜜夜内射|