在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. TUBB1 Monoclonal Antibody

TUBB1 Monoclonal Antibody

  • 中文名稱：
    TUBB1鼠單克隆抗體
  • 貨號：
    CSB-MA000192
  • 規格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Hela, 2) Mouse Brain Tissue, 3) Rat Brain Tissue, diluted at 1:5000.
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA000192 TUBB1單克隆抗體是針對β-微管蛋白家族成員TUBB1研發的特異性檢測工具，該靶點在血小板形成過程中發揮關鍵作用，參與調控巨核細胞分化和血小板釋放機制，其表達異常與血小板減少癥等血液系統疾病密切相關。本產品采用雜交瘤技術制備，具有高親和力與優異特異性，可精準識別人類、小鼠及大鼠樣本中TUBB1蛋白，適用于ELISA檢測和Western Blot免疫印跡實驗，滿足不同實驗體系需求。經嚴格驗證的抗體性能可有效支持血小板生成機制研究、巨核細胞分化過程分析以及血小板相關疾病的分子機制探索，為血液系統疾病研究、心血管病理模型構建及藥物作用靶點篩選等科研領域提供可靠工具。該TUBB1抗體特別適用于體外培養細胞模型、組織裂解液等樣本的蛋白水平檢測，兼容常規SDS-PAGE及轉膜實驗條件，是研究細胞骨架動態調控與血小板功能關聯性的理想選擇。
  • Uniprot No.：
  • 基因名：
  • 別名：
    2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H, R, M
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    29E1
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻：
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
    3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
    4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
    5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
    6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
    7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
    8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
    9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
    10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
    11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
    12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
    13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
    14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
    15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255

    顯示更多

    收起更多

  • 相關疾病：
    Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
  • 數據庫鏈接：

    HGNC: 16257

    OMIM: 612901

    KEGG: hsa:81027

    STRING: 9606.ENSP00000217133

    UniGene: Hs.303023



主站蜘蛛池模板： 久久99热狠狠色精品一区| 久久久久影院美女国产主播| 色噜噜噜亚洲男人的天堂| 成在人线无码aⅴ免费视频| 青青草视频在线观看 | 亚洲性夜色噜噜噜在线观看不卡| 色优久久久久综合网鬼色| 国产丝袜美女一区二区三区| 欧美一区内射最近更新| 超碰香蕉人人网99精品| 亚洲成av人片在www| 香草乱码一二三四区别| 99久久99久久精品免费观看| 色情无码www视频无码区小黄鸭| 久久久精品区二区三区免费| 日本熟妇人妻xxxxx-欢迎您| 亚洲精品久久久久一区二区三区| 国产综合内射日韩久| 蜜臀av午夜一区二区三区| 人人妻人人爽人人澡欧美一区| 青青草国产精品人人爱| 极品少妇高潮到爽| 国产成人无码一区二区在线观看| 精品三级av无码一区| 女人高潮抽搐潮喷小视频| 欧美综合区自拍亚洲综合绿色| 无码国产精品一区二区色情男同 | 欧美大屁股流白浆xxxx| 国厂精品114福利电影免费| 久久天天躁狠狠躁夜夜爽| 久本草在线中文字幕亚洲| 丰满饥渴老女人hd| 老司机深夜18禁污污网站| 热99re久久国超精品首页| 亚洲а∨精品天堂在线| 朝鲜美女黑毛bbw| 5x性社区免费视频播| 日韩精品无码人成视频| 中文字幕资源网| 国产精品igao视频| 久久国产成人免费网站777|