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  4. TRIM39 Antibody

TRIM39 Antibody

  • 中文名稱：
    TRIM39兔多克隆抗體
  • 貨號：
    CSB-PA881029LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, NIH/3T3 whole cell lysate, Mouse skeletal muscle tissue
      All lanes: TRIM39 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60, 57 kDa
      Observed band size: 45, 50 kDa
    • IHC image of CSB-PA881029LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of Hela cells using CSB-PA881029LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TRIM39 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TRIM39
  • 別名：
    HGNC:10065 antibody; MGC32984 antibody; RING finger protein 23 antibody; RNF23 antibody; Testis abundant finger protein antibody; Testis-abundant finger protein antibody; TFP antibody; TFP RING FINGER PROTEIN 23 antibody; TRI39_HUMAN antibody; Trim39 antibody; TRIM39B antibody; Tripartite motif containing 39 antibody; Tripartite motif-containing protein 39 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM39 protein (310-416AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TRIM39 Antibody (CSB-PA881029LA01HU)，的標記方式是Non-conjugated。對于TRIM39 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA881029LB01HU TRIM39 Antibody, HRP conjugated ELISA
    FITC CSB-PA881029LC01HU TRIM39 Antibody, FITC conjugated
    Biotin CSB-PA881029LD01HU TRIM39 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.; Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner.
  • 基因功能參考文獻：
    1. TRIM39 negatively regulates the NFkappaB signaling pathway possibly via stabilization of cactin. PMID: 26363554
    2. TRIM39R, but not TRIM39B, regulates type I interferon response PMID: 23707810
    3. TRIM39 has a role in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing p21 PMID: 23213251
    4. analysis of ubiquitylation of p53 by the APC/C inhibitor Trim39 PMID: 23213260
    5. these findings suggest that RNF39 and TRIM39 are involved in the etiology of Behcet's disease. PMID: 20875797
    6. Data suggest that TRIM39 can promote apoptosis signalling through stabilization of MOAP-1. PMID: 19100260

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  • 亞細胞定位：
    [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus.; [Isoform 2]: Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 組織特異性：
    Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
  • 數據庫鏈接：

    HGNC: 10065

    OMIM: 605700

    KEGG: hsa:56658

    STRING: 9606.ENSP00000365844

    UniGene: Hs.413493



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