在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TMEM127 Antibody

TMEM127 Antibody

  • 中文名稱：
    TMEM127兔多克隆抗體
  • 貨號：
    CSB-PA023694LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA023694LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA023694LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TMEM127 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TMEM127
  • 別名：
    TMEM127; Transmembrane protein 127
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 127 protein (1-95AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TMEM127 Antibody (CSB-PA023694LA01HU)，的標記方式是Non-conjugated。對于TMEM127 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA023694LB01HU TMEM127 Antibody, HRP conjugated ELISA
    FITC CSB-PA023694LC01HU TMEM127 Antibody, FITC conjugated
    Biotin CSB-PA023694LD01HU TMEM127 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
  • 基因功能參考文獻：
    1. Of which 4 SDHB and 2 TMEM127 mutations were novel. PMID: 26960314
    2. Hereditary pheochromocytoma / paraganglioma associated with TMEM127 gene mutations has more aggressive course,bilateral adrenal involvement, higher recurrence rate, younger age at disease manifestations. PMID: 26591561
    3. We report the first case of an individual with both a pheochromocytoma and a multilocular clear cell renal cell carcinoma driven by a novel germline mutation in the TMEM127 gene, with a sibling and 2 sons with the same mutation. PMID: 25800244
    4. Tumor multicentricity, nodular adrenomedullary hyperplasia, and the occurrence of symptoms more than a decade earlier than the age at diagnosis are novel findings in TMEM127-related pheochromocytoma. PMID: 25389632
    5. A male patient with sporadic adrenal pheochromocytoma presents with a novel TMEM127 germline mutation, p. Gln139X. PMID: 23551308
    6. TMEM127 protein localizes in lysosomes in HeLa cells PMID: 21752829
    7. report shows that TMEM127 mutation plays a pathological role in pheochromocytoma in an Asian population. PMID: 22541004
    8. TMEM127 is a novel pheochromocytoma susceptibility gene.[review] PMID: 21447639
    9. TMEM127 germline mutations confer risks of extraadrenal paraganglial tumors in addition to the documented adrenal pheochromocytoma. PMID: 21613359
    10. Pathological and genomic data demonstrated that a TMEM127 gene mutation not previously described was causative of a new case of familial bilateral pheochromocytoma. PMID: 20923864
    11. Germline mutations of FP/TMEM127 were associated with pheochromocytoma but not paraganglioma and occurred in an age group frequently excluded from genetic screening algorithms; mutations disrupt intracellular distribution of the FP/TMEM127 protein. PMID: 21156949
    12. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma and identify TMEM127 as a tumor suppressor gene. PMID: 20154675

    顯示更多

    收起更多

  • 相關疾病：
    Pheochromocytoma (PCC)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm.
  • 蛋白家族：
    TMEM127 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 26038

    OMIM: 171300

    KEGG: hsa:55654

    STRING: 9606.ENSP00000258439

    UniGene: Hs.164303



主站蜘蛛池模板： 亚洲伦无码中文字幕另类| 国产偷伦视频片免费视频| 国产偷窥熟精品视频| 国产精品无码一区二区在线看| 久久这里精品国产99丫e6| 啦啦啦中文在线观看日本| 久久综合久久88中字幕文| 2021无码天堂在线| a亚洲va欧美va国产综合| 99国产精品久久久久久久成人| 国产成人精品久久久久精品日日| 久久精品国产亚洲不av麻豆| 婷婷色婷婷开心五月四房播播| 国产欧美精品一区二区三区-老狼| 亚洲精品无码高潮喷水a片软| 香港三级日本三级韩级人妇| 又粗又硬又大又爽免费视频播放| 麻花传媒mv在线观看| 亚洲成av人片天堂网老年人| 99久久99久久免费精品蜜桃 | 无码少妇a片一区二区三区| 欧美黑人巨大videos精品男男| 亚洲成av人片在线观l看福利1| 欧美牲交a欧美牲交aⅴ免费真| 中文无码精品a∨在线观看不卡| 人妻无码少妇一区二区| 亚洲欧美成人一区二区在线电影 | 天天av天天翘天天综合网色鬼| 又黄又爽又猛的视频免费| 97久章草在线视频播放| 涩欲国产一区二区三区四区| 久久久久久综合网天天| 国产人成网线在线播放va| 久久天天躁狠狠躁夜夜2o2o| 久久综合久色欧美综合狠狠| 欧洲熟妇色xxxx欧美老妇老头多毛| 激情综合婷婷丁香五月情| 96国产xxxx免费视频| 国产亚洲美女精品久久久| 狠狠色狠狠色五月激情| 亚洲成a人片在线观看天堂无码 |