在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TLK2 Antibody

TLK2 Antibody

  • 中文名稱：
    TLK2兔多克隆抗體
  • 貨號：
    CSB-PA023592GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TLK2
  • 別名：
    MGC44450 antibody; PKU alpha antibody; PKU-alpha antibody; Serine/threonine kinase antibody; Serine/threonine protein kinase tousled like 2 antibody; Serine/threonine-protein kinase tousled-like 2 antibody; TLK 2 antibody; tlk2 antibody; TLK2_HUMAN antibody; Tousled like kinase 2 antibody; Tousled-like kinase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human TLK2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
  • 基因功能參考文獻：
    1. haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. PMID: 29861108
    2. Molecular basis of TLK2 activation and inhibition has been dissected. PMID: 29955062
    3. TLK2 is amplified in aggressive luminal breast neoplasms PMID: 27694828
    4. Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest. PMID: 26931568
    5. Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage. PMID: 27489360
    6. TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation. PMID: 23414760
    7. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks. PMID: 21647934
    8. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases. PMID: 20016786

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 11842

    OMIM: 608439

    KEGG: hsa:11011

    STRING: 9606.ENSP00000275780

    UniGene: Hs.445078



主站蜘蛛池模板： 2020最新无码国产在线观看| 99久re热视频这里只有精品6| 日韩制服国产精品一区| 免费人成视频在线播放视频 | 国产亚洲人成a在线v网站| 在线不卡日本v一区二区| 无码动漫性爽xo视频在线观看| 亚洲伊人情人综合网站| 印度女人狂野牲交| 人妻少妇中文字幕久久| 亚洲午夜无码毛片av久久京东热| 永久黄网站免费视频性色| 狠狠色噜噜狠狠狠狠蜜桃| 麻花传媒mv国产免费观看视频| 狠狠躁夜夜躁人人爽天天天天| 性按摩xxxx在线观看| 在线岛国片免费无码av| 99这里有精品视频视频| 精品精品国产高清a毛片| 欧美黑人疯狂性受xxxxx喷水| 极品嫩模高潮叫床| 国产一区二区三区在线电影| 免费国产成人高清在线视频| 中文字字幕在线精品乱码| 成人丝袜激情一区二区| 婷婷久久综合九色综合88| 亚洲欧美日韩在线码| 日本一上一下爱爱免费| 亚洲 欧美 唯美 国产 伦 综合| 国产乱人激情h在线观看| 亚洲有无码av在线播放| 午夜福制92视频| 色yeye香蕉凹凸视频在线观看| 国产精品.xx视频.xxtv| 97国产精品人妻无码久久久| 体验区试看120秒啪啪免费| 伊人久久大香线蕉无码| 在线播放五十路熟妇| 樱花草在线社区www中国中文| 青青久久成人免费影院| 国产精品偷伦视频免费观看了|