在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TLK2 Antibody

TLK2 Antibody

  • 中文名稱：
    TLK2兔多克隆抗體
  • 貨號：
    CSB-PA004304
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using TLK2 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TLK2
  • 別名：
    MGC44450 antibody; PKU alpha antibody; PKU-alpha antibody; Serine/threonine kinase antibody; Serine/threonine protein kinase tousled like 2 antibody; Serine/threonine-protein kinase tousled-like 2 antibody; TLK 2 antibody; tlk2 antibody; TLK2_HUMAN antibody; Tousled like kinase 2 antibody; Tousled-like kinase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TLK2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
  • 基因功能參考文獻：
    1. haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. PMID: 29861108
    2. Molecular basis of TLK2 activation and inhibition has been dissected. PMID: 29955062
    3. TLK2 is amplified in aggressive luminal breast neoplasms PMID: 27694828
    4. Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest. PMID: 26931568
    5. Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage. PMID: 27489360
    6. TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation. PMID: 23414760
    7. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks. PMID: 21647934
    8. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases. PMID: 20016786

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 11842

    OMIM: 608439

    KEGG: hsa:11011

    STRING: 9606.ENSP00000275780

    UniGene: Hs.445078



主站蜘蛛池模板： 国产亚洲精品a片久久久| 人妻三级日本香港三级极| 亚洲欧洲自偷自拍图片| 97精品国产一区二区三区四区 | 国产卡一卡二卡三| 国产精品无码成人午夜电影| 77777五月色婷婷丁香视频| 人人爽人人爽人人片a免费| 国产无人区码一码二码三mba| 中文字幕无线码免费人妻| 碰超免费人妻中文字幕| 潮喷失禁大喷水av无码| 精品无人国产偷自产在线| 国产网红主播无码精品| 在线 亚洲 国产 欧美| 国产av综合第一页| 欧美丰满熟妇bbbbbb| 女邻居的大乳中文字幕| 国产超碰人人做人人爽av动图| 精品国产自在现线看久久| 精品无码无人网站免费视频| 2017亚洲天堂最新地址| 亚洲桃色天堂网| 久久成人a毛片免费观看网站| 亚洲产国偷v产偷v自拍色戒| 亚洲 欧美 日产 综合 在线| 久久99精品久久久久久9蜜桃| 亚洲 欧美 日韩 综合aⅴ| 久99久热只有精品国产女同| 乱色国内精品视频在线| 中文字幕美人妻亅u乚一596| 乱码丰满人妻一二三区| 亚洲精品无码久久毛片波多野吉衣 | 国产麻豆剧果冻传媒一区| 久久天天躁夜夜躁狠狠躁2014| 亚洲国产成人无码电影| 欧美日韩午夜群交多人轮换| 无码精品久久一区二区三区| 亚洲人成电影综合网站色www| 无码丰满熟妇juliaann与黑人| 久久精品国产一区二区三区|