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  4. TIPARP Antibody, HRP conjugated

TIPARP Antibody, HRP conjugated

  • 中文名稱：
    TIPARP兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA801800LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TIPARP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ADP-ribosyltransferase diphtheria toxin-like 14 antibody; ARTD14 antibody; AW558171 antibody; DDF1 antibody; DKFZp434J214 antibody; DKFZp686N0351 antibody; DKFZp686P1838 antibody; FLJ40466 antibody; PARP 1 antibody; PARP 7 antibody; PARP-7 antibody; PARPT_HUMAN antibody; pART14 antibody; Poly [ADP ribose] polymerase 7 antibody; Poly [ADP-ribose] polymerase 7 antibody; TCDD inducible poly(ADP ribose) polymerase antibody; TCDD-inducible poly [ADP-ribose] polymerase antibody; TIPARP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TCDD-inducible poly [ADP-ribose] polymerase protein (74-178AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR.
  • 基因功能參考文獻(xiàn)：
    1. TIPARP is a viral RNA-sensing pattern recognition receptors that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage PMID: 28213497
    2. Moreover, time course and promoter activity assays suggest that TIPARP and TIPARP-AS1 work in concert to regulate AHR signaling. Collectively, these data show an added level of complexity in the AHR signaling cascade which involves lncRNAs, whose functions remain poorly understood. PMID: 29274782
    3. Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels. PMID: 24806346
    4. Single nucleotide polymorphism in TIPARP is associated with ovarian cancer. PMID: 20852632
    5. TIPARP (DKFZp434J214) gene is amplified in HNSCC. TIPARP, FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID: 12851707

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  • 亞細(xì)胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23696

    OMIM: 612480

    KEGG: hsa:25976

    STRING: 9606.ENSP00000295924

    UniGene: Hs.744050



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