在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TIFA Antibody

TIFA Antibody

  • 中文名稱：
    TIFA兔多克隆抗體
  • 貨號：
    CSB-PA839301LA01HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TIFA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TIFA
  • 別名：
    Putative MAPK activating protein PM14 antibody; Putative MAPK-activating protein PM14 antibody; Putative NF kappa B activating protein 20 antibody; Putative NF-kappa-B-activating protein 20 antibody; T2BP antibody; TIFA antibody; TIFA_HUMAN antibody; TRAF interacting protein with FHA domain containing protein A antibody; TRAF-interacting protein with FHA domain-containing protein A antibody; TRAF2 binding protein antibody; TRAF2-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF-interacting protein with FHA domain-containing protein A protein (1-184AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TIFA Antibody (CSB-PA839301LA01HU)，的標記方式是Non-conjugated。對于TIFA Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA839301LB01HU TIFA Antibody, HRP conjugated ELISA
    FITC CSB-PA839301LC01HU TIFA Antibody, FITC conjugated
    Biotin CSB-PA839301LD01HU TIFA Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

產品評價

靶點詳情

  • 功能：
    Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
  • 基因功能參考文獻：
    1. TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. PMID: 29975933
    2. TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 PMID: 27965388
    3. study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells PMID: 28811347
    4. These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. PMID: 28514661
    5. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA PMID: 28069801
    6. This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). PMID: 26389808
    7. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. PMID: 26068852
    8. identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation PMID: 22566686
    9. TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism PMID: 15492226

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 19075

    OMIM: 609028

    KEGG: hsa:92610

    STRING: 9606.ENSP00000354911

    UniGene: Hs.310640



主站蜘蛛池模板： 少妇系列之白嫩人妻| а√天堂资源官网在线资源| 特黄 做受又硬又粗又大视频| av狠狠色超碰丁香婷婷综合久久| 国产亚洲欧美日韩精品一区二区| 四虎www成人影院观看| 久久国产欧美日韩精品| 色情无码一区二区三区| 日韩国产网曝欧美第一页| 人成午夜免费视频无码| 亚洲丁香五月天缴情综合| 少妇太爽了在线观看免费视频| 久久精品国产福利一区二区| 国产经典三级av在线播放| 人人狠狠综合久久亚洲爱咲| 国产欧美在线观看不卡| 国产suv精品一区二区6| 国产白丝精品爽爽久久久久久蜜臀| 2019最新中文字幕在线观看| 亚洲精品一区二区三区四区五区| 福利视频在线播放| 免费人成视频在线观看不卡| av无码国产在线看免费网站| 蜜臀av无码精品人妻色欲| 日韩久久无码免费毛片软件| 女人扒下裤让男人桶到爽| 伊人色合天天久久综合网| 国产艳妇av在线观看果冻传媒| 久久久一本精品99久久精品66| 国产在线不卡人成视频| 2020国产精品午夜福利在线观看 | 欧美不卡一区二区三区| 亚洲中文无码a∨在线观看| 亚洲免费福利在线视频| 欧美写真视频在线观看| 久久精品国产亚洲精品| 日韩插啊免费视频在线观看| 人妻.中文字幕无码| 国产农村妇女毛片精品久久| 亚洲国产综合精品 在线 一区| 欧美成人一卡二卡三卡四卡|