在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TIFA Antibody, FITC conjugated

TIFA Antibody, FITC conjugated

  • 中文名稱：
    TIFA兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA839301LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TIFA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TIFA
  • 別名：
    Putative MAPK activating protein PM14 antibody; Putative MAPK-activating protein PM14 antibody; Putative NF kappa B activating protein 20 antibody; Putative NF-kappa-B-activating protein 20 antibody; T2BP antibody; TIFA antibody; TIFA_HUMAN antibody; TRAF interacting protein with FHA domain containing protein A antibody; TRAF-interacting protein with FHA domain-containing protein A antibody; TRAF2 binding protein antibody; TRAF2-binding protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF-interacting protein with FHA domain-containing protein A protein (1-184AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
  • 基因功能參考文獻(xiàn)：
    1. TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. PMID: 29975933
    2. TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 PMID: 27965388
    3. study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells PMID: 28811347
    4. These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. PMID: 28514661
    5. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA PMID: 28069801
    6. This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). PMID: 26389808
    7. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. PMID: 26068852
    8. identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation PMID: 22566686
    9. TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism PMID: 15492226

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19075

    OMIM: 609028

    KEGG: hsa:92610

    STRING: 9606.ENSP00000354911

    UniGene: Hs.310640



主站蜘蛛池模板： 久久www成人_看片免费不卡| 欧美老熟妇牲交| 免费无码成人片| 人妻丰满熟妇av无码片| 国产一本一道久久香蕉| 欧洲人妻丰满av无码久久不卡 | 国产欧美日韩中文久久| 大肉大捧一进一出好爽视频| 国产极品白嫩精品| 国产精品爱啪在线播放| 亚洲春色av无码专区在线播放| 国产亚洲精品第一综合麻豆| 少妇无码av无码专区在线观看| 中文字幕无码免费不卡视频| 久久亚洲人成电影网| 综合图区亚洲欧美另类图片| 欧美激情性做爰免费视频| 久久综合九色综合97网| 黑人与人妻无码中字视频| 色欲色香天天天综合vvv| 天堂а√中文在线官网| 国产精品点击进入在线影院高清 | 国产精品高清不卡在线播放 | 99尹人香蕉国产免费天天 | 少妇被多人c夜夜爽爽| 任我撸在线视频| 无遮挡激情视频国产在线观看| 成人无码一区二区三区网站| 亚洲中文字幕无码一区| 女邻居的大乳中文字幕| 动漫成人无码精品一区二区三区| 日韩精品久久久久久免费| 国产精品免费一区二区三区四区 | 精品无码久久久久国产电影| 国产女人18毛片水真多18精品| 色婷婷综合久久久久中文字幕| 久久久久精品无码一区二区三区| 亚洲乱色熟女一区二区三区丝袜| 麻豆精品导航| 中文 在线 日韩 亚洲 欧美| 久草热久草热线频97精品|