在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TIFA Antibody, HRP conjugated

  • 中文名稱:
    TIFA兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA839301LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TIFA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TIFA
  • 別名:
    Putative MAPK activating protein PM14 antibody; Putative MAPK-activating protein PM14 antibody; Putative NF kappa B activating protein 20 antibody; Putative NF-kappa-B-activating protein 20 antibody; T2BP antibody; TIFA antibody; TIFA_HUMAN antibody; TRAF interacting protein with FHA domain containing protein A antibody; TRAF-interacting protein with FHA domain-containing protein A antibody; TRAF2 binding protein antibody; TRAF2-binding protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human TRAF-interacting protein with FHA domain-containing protein A protein (1-184AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of proinflammatory NF-kappa-B signaling.
  • 基因功能參考文獻:
    1. TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. PMID: 29975933
    2. TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 PMID: 27965388
    3. study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells PMID: 28811347
    4. These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. PMID: 28514661
    5. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA PMID: 28069801
    6. This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). PMID: 26389808
    7. an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. PMID: 26068852
    8. identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation PMID: 22566686
    9. TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism PMID: 15492226

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 數據庫鏈接:

    HGNC: 19075

    OMIM: 609028

    KEGG: hsa:92610

    STRING: 9606.ENSP00000354911

    UniGene: Hs.310640



主站蜘蛛池模板: 窝窝午夜看片| 性男女做视频观看网站| 内射一区二区精品视频在线观看| 无码中文字幕乱在线观看| 国产精品亚洲一区二区三区在线| 久久久老熟女一区二区三区| 色欲av亚洲情无码av蜜桃| 久久人人97超碰caoporen| 538在线精品视频| 黄瓜视频在线观看| 国产成人精品视频网站| 日本 精品 高清不卡| 性欧美熟妇videofreesex| 337人体做爰大胆视频| 波多老师无码av中字专区| 亚洲欧洲国产成人综合在线观看| 抽插丰满内射高潮视频| 西西人体大胆瓣开下部毛茸茸| 国产福利自产拍| 国产免费牲交视频| 国内精品伊人久久久久7777| 真人做人60分钟啪啪免费看| 人妻系列无码专区免费视频| 欧美乱妇高清无乱码| 亚洲天堂2017无码| 欧美另类又黄又爽的a片 | 成人性做爰aaa片免费看曹查理| 精品国产乱码久久久久久郑州公司| av无码中文一区二区三区四区| 国产精品三级av三级av三级| 无码熟妇人妻av在线电影| aa片在线观看视频在线播放| 无码国内精品久久人妻蜜桃| 久久久综合九色合综| 国产精品自在线拍国产手机版| 亚洲gv天堂gv无码男同| 嫩草国产福利视频一区二区| 国产精品无码专区| 成年男人裸j照无遮挡无码| 无码专区亚洲制服丝袜| 野花社区在线观看视频|