在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TBC1D23 Antibody

  • 中文名稱:
    TBC1D23兔多克隆抗體
  • 貨號:
    CSB-PA023198GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TBC1D23
  • 別名:
    DKFZp667G062 antibody; FLJ11046 antibody; HCV non-structural protein 4A-transactivated protein 1 antibody; NS4ATP1 antibody; TBC1 domain family member 23 antibody; TBC1D23 antibody; TBC23_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human TBC1D23
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
  • 基因功能參考文獻:
    1. The Rab GAP domain of TBC1D23 binds to a conserved motif at the tip of golgin-245 and golgin-97 at the trans-Golgi, while the C terminus binds to the WASH complex on endosome-derived vesicles. Thus, TBC1D23 is a specificity determinant that links the vesicle to the target membrane during endosome-to-Golgi trafficking. PMID: 29084197
    2. Homozygous Mutations in TBC1D23 gene are associated with Non-degenerative Form of Pontocerebellar Hypoplasia. PMID: 28823706
    3. Homozygous Truncating Variants in TBC1D23 gene are associated with Pontocerebellar Hypoplasia and Alter Cortical Development. PMID: 28823707
  • 相關疾?。?/div>
    Pontocerebellar hypoplasia 11 (PCH11)
  • 亞細胞定位:
    Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle.
  • 組織特異性:
    Isoform 1: Widely expressed, including in fetal adult brain (corpus callosum, pons, cerebellum), spinal cord, heart, skeletal muscle, thymus and bone marrow, and at lower levels in spleen. Hardly detected in liver, kidney, colon and testis. Isoform 2: Exp
  • 數據庫鏈接:

    HGNC: 25622

    OMIM: 617687

    KEGG: hsa:55773

    STRING: 9606.ENSP00000377700

    UniGene: Hs.477003



主站蜘蛛池模板: 日本www一道久久久免费| 国产色诱视频在线观看| 中国女人高潮hd| 亚洲 日韩 国产欧美 另类| 天天爱天天做久久狠狠做| 丝袜无码一区二区三区| 国产精品久久久久永久免费看| 国产露脸150部国语对白| 欧美乱码卡一卡二卡三新区| 天堂久久天堂av色综合| 潮喷大喷水系列无码视频| 天天狠天天天天透在线| 久久欧美与黑人双交男男| 精品乱子伦一区二区三区| 国产熟妇乱子伦视频在线观看| 国产午夜福利精品一区| 久久久久久99av无码免费网站| 亚洲国产精彩中文乱码av| 少妇无码一区二区三区| 免费国产黄网站在线观看| 艳妇荡女欲乱双飞两中年熟妇| 久久精品伊人一区二区三区| 2021最新国产精品网站| 侵犯强奷高清无码| 99re6热精品视频在线观看| 国产一区二区精品久久| 中文字幕av无码不卡| 熟女内射v888av| 无码成人精品区在线观看| 精品无码成人片一区二区98| 精品亚洲aⅴ在线无码播放| 久久大香线蕉国产精品免费| 亚洲色成人四虎在线观看| 宅男宅女精品国产av天堂| 亚洲 综合 校园 欧美 制服| 亚洲 日韩 国产 中文有码| 亚洲熟妇无码一区二区三区导航| 久久这里只精品国产免费10| 中文字幕乱码亚洲无线三区| 女人扒开屁股桶爽30分钟| 亚洲精品久久久久玩吗|