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  4. TAX1BP3 Antibody

TAX1BP3 Antibody

  • 中文名稱：
    TAX1BP3兔多克隆抗體
  • 貨號：
    CSB-PA04445A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: TAX1BP3 antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 14 kDa
      Observed band size: 70 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAX1BP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Glutaminase interacting protein 3 antibody; Glutaminase-interacting protein 3 antibody; Tax interaction protein 1 antibody; Tax1 (human T cell leukemia virus type I) binding protein 3 antibody; Tax1 binding protein 3 antibody; Tax1-binding protein 3 antibody; Tax1bp3 antibody; TIP 1 antibody; TIP-1 antibody; TIP1 antibody; TX1B3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tax1-binding protein 3 protein (1-124AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TAX1BP3 Antibody (CSB-PA04445A0Rb)，的標記方式是Non-conjugated。對于TAX1BP3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA04445B0Rb TAX1BP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA04445C0Rb TAX1BP3 Antibody, FITC conjugated
    Biotin CSB-PA04445D0Rb TAX1BP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
  • 基因功能參考文獻：
    1. Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia PMID: 25645515
    2. ARHGEF7, a guanine nucleotide exchange factor for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells PMID: 23563176
    3. this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. PMID: 23395680
    4. The study provided the first evidence showing that TIP-1 modulates p53 protein stability and is involved in the radioresistance of malignant gliomas. PMID: 23028987
    5. The study reports the identification of 18 new glutaminase-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase-interacting protein partner proteins. PMID: 22876914
    6. this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers. PMID: 22564736
    7. HPV16 E6, Tip-1 and ARHGEF16 may cooperate to activate Cdc42 and support a potential link between the expression of HPV16 E6 and Cdc42 activation. PMID: 21139582
    8. This is the first study reporting BAI2 as an interaction partner of GIP. PMID: 21787750
    9. TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway PMID: 12874278
    10. HPV16 E6 protein may increase cell motility by augmenting GTP RhoA mediated activation of RhoA kinases and that this is dependent on the expression of the Tip-1 protein PMID: 15492812
    11. TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand. PMID: 16855024
    12. the overexpression, efficient refolding, single-step purification, and biophysical characterization of recombinant human TIP-1 with three different C-terminal target protein recognition sequence motifs by CD, fluorescence, and NMR methods PMID: 18690705
    13. TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3. PMID: 19635485

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.
  • 組織特異性：
    Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 30684

    OMIM: 616476

    KEGG: hsa:30851

    STRING: 9606.ENSP00000225525

    UniGene: Hs.12956



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