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  4. Smox Antibody, Biotin conjugated

Smox Antibody, Biotin conjugated

  • 中文名稱：
    Smox兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA021844YD01MO
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Smox Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Smox antibody; SmoSpermine oxidase antibody; EC 1.5.3.16 antibody; Polyamine oxidase 1 antibody; PAO-1 antibody; PAOh1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Spermine oxidase protein (1-555AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
  • 基因功能參考文獻：
    1. Novel evidences of the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain. PMID: 23840306
    2. Spermine oxidase is an important regulator of muscle gene expression and fiber size. PMID: 25406264
    3. Data (including data from studies using recombinant mutant proteins) suggest that Glu216-Ser218 is a hot spot responsible for Smox substrate specificity; Smox with mutation E216L/S218A exhibits specificity for N'-acetylspermine rather than spermine. PMID: 24854736
    4. ROS overexposure by mSMOX delivers an earlier adaptive response to radiation PMID: 23857253
    5. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. PMID: 21839041
    6. Spermine oxidase binds spermine in a similar conformation as that observed in the yeast polyamine oxidase FMS1-spermine complex and demonstrate a major role for residues His82 and Lys367 in substrate binding and catalysis. PMID: 20839014
    7. expression and characterization of mouse spermine oxidase PMID: 12458219
    8. we identified a second domain that is necessary for nuclear localization of the spermine oxidase splice variant PMID: 15955064

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  • 亞細胞定位：
    Cytoplasm.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 組織特異性：
    Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung.
  • 數據庫鏈接：

    KEGG: mmu:228608

    UniGene: Mm.136586



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