在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STRA6 Antibody, HRP conjugated

  • 中文名稱:
    STRA6兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA866301LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STRA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STRA6
  • 別名:
    MCOPCB8 antibody; MCOPS9 antibody; PP14296 antibody; Stimulated by retinoic acid 6 homolog antibody; Stimulated by retinoic acid gene 6 protein homolog antibody; STRA6 antibody; STRA6_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor for retinol uptake STRA6 protein (530-667AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
  • 基因功能參考文獻:
    1. Mutations in retinoic acid 6 gene (STRA6) have been reported in clinically diagnosed patients with MWS. Here we presented a case with MWS, who has characteristic findings of the syndrome as well as dextrocardia as an undescribed feature, and bilateral streak gonads which was described only in one patient previously. Molecular analysis showed a homozygous exonic missense mutation in the STRA6 gene. PMID: 30204971
    2. The knockdown of STRA6 slightly enhanced nodule formation at the late stage of osteoblast differentiation, and overexpression of STRA6 in ST2 cells enhanced adipocyte differentiation. PMID: 29067460
    3. these data demonstrate a key role of STRA6 and RBP4 in the maintenance of colon cancer self-renewal and that this pathway is an important link through which consumption of HFD contributes to colon carcinogenesis. PMID: 28689994
    4. this study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of type 2 diabetes mellitus(T2DM) while RARRES2 polymorphism could not predict the risk of T2DM PMID: 27446956
    5. A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly. PMID: 26373900
    6. These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers. PMID: 25237067
    7. Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6. PMID: 24223695
    8. STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells PMID: 24284421
    9. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. PMID: 23449393
    10. Analysis of FRAS1 and STRA6 mutations in the same family with eye anomalies. PMID: 22283518
    11. Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities. PMID: 22686418
    12. TTR blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling. PMID: 22826435
    13. STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin. PMID: 22665496
    14. STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS. PMID: 21901792
    15. SNPs in STRA6, gene coding the cell surface receptor for RBP4, were significantly associated with type 2 diabetes and further genetic and functional studies are required to understand and ascertain its role in the manifestation of type 2 diabetes. PMID: 20625434
    16. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation PMID: 17273977
    17. Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. PMID: 17503335
    18. In fibroboasts, STRA6 transports retinol bidirectionally in an RBP4 dependent manner. PMID: 18316031
    19. study identifies an essential functional domain in STRA6 and a human polymorphism in this domain that leads to reduced vitamin A uptake activity PMID: 18387951
    20. This study explores the association of STRA6 and SKI genes in a cohort of subjects with anophthalmia and microphthalmia. PMID: 19112531
    21. Two novel STRA6 mutations in a patient with anophthalamia and diaphragmatic eventration are reported. PMID: 19213032
    22. Six novel mutations were identified in STRA6. PMID: 19309693

    顯示更多

    收起更多

  • 相關疾病:
    Microphthalmia, syndromic, 9 (MCOPS9)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性:
    Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
  • 數據庫鏈接:

    HGNC: 30650

    OMIM: 601186

    KEGG: hsa:64220

    STRING: 9606.ENSP00000456609

    UniGene: Hs.24553



主站蜘蛛池模板: 99精品国产一区二区三区不卡| 欧美日韩午夜群交多人轮换| 欧美激情视频一区二区三区免费| 久久人妻少妇嫩草av无码专区| 亚洲欧美综合区丁香五月小说| 欧美成aⅴ人高清怡红院| 成人av久久一区二区三区| 欧美综合区自拍亚洲综合绿色| 亚洲午夜精品久久久久久app| 中文无码av一区二区三区| 国产乱码人妻一区二区三区四区| 精品无码综合一区二区三区| 欧美国产伦久久久久久久| 久久99亚洲精品久久频| 亚瑟国产精品久久| 麻豆 美女 丝袜 人妻 中文| 小说区亚洲综合第1页| 国产无遮挡a片又黄又爽漫画 | 国产精品久久久久高潮| 亚洲精品乱码久久久久久日本 | 香蕉av777xxx色综合一区| 漂亮人妻去按摩被按中出| 久久亚洲精品无码播放| 日日碰狠狠躁久久躁96| 无码人妻少妇久久中文字幕蜜桃| 日本不卡一区二区三区| 亚洲色偷精品一区二区三区| 日韩精品乱码av一区二区| 成人无码av一区二区三区| 亚洲欧洲日本综合aⅴ在线| 午夜不卡av免费| 欧美老熟妇又粗又大| 播五月开心婷婷欧美综合| 日本少妇寂寞少妇aaa| 国产亚洲精品精华液| 精品久久久久久无码免费| 成人片无码免费播放| 啪一啪射一射插一插| 成人爽a毛片免费啪啪| 在线亚洲欧美日韩精品专区| 国产免费人成网站x8x8|