在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STRA6 Antibody, FITC conjugated

  • 中文名稱:
    STRA6兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA866301LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STRA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STRA6
  • 別名:
    MCOPCB8 antibody; MCOPS9 antibody; PP14296 antibody; Stimulated by retinoic acid 6 homolog antibody; Stimulated by retinoic acid gene 6 protein homolog antibody; STRA6 antibody; STRA6_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor for retinol uptake STRA6 protein (530-667AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
  • 基因功能參考文獻:
    1. Mutations in retinoic acid 6 gene (STRA6) have been reported in clinically diagnosed patients with MWS. Here we presented a case with MWS, who has characteristic findings of the syndrome as well as dextrocardia as an undescribed feature, and bilateral streak gonads which was described only in one patient previously. Molecular analysis showed a homozygous exonic missense mutation in the STRA6 gene. PMID: 30204971
    2. The knockdown of STRA6 slightly enhanced nodule formation at the late stage of osteoblast differentiation, and overexpression of STRA6 in ST2 cells enhanced adipocyte differentiation. PMID: 29067460
    3. these data demonstrate a key role of STRA6 and RBP4 in the maintenance of colon cancer self-renewal and that this pathway is an important link through which consumption of HFD contributes to colon carcinogenesis. PMID: 28689994
    4. this study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of type 2 diabetes mellitus(T2DM) while RARRES2 polymorphism could not predict the risk of T2DM PMID: 27446956
    5. A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly. PMID: 26373900
    6. These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers. PMID: 25237067
    7. Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6. PMID: 24223695
    8. STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells PMID: 24284421
    9. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. PMID: 23449393
    10. Analysis of FRAS1 and STRA6 mutations in the same family with eye anomalies. PMID: 22283518
    11. Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities. PMID: 22686418
    12. TTR blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling. PMID: 22826435
    13. STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin. PMID: 22665496
    14. STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS. PMID: 21901792
    15. SNPs in STRA6, gene coding the cell surface receptor for RBP4, were significantly associated with type 2 diabetes and further genetic and functional studies are required to understand and ascertain its role in the manifestation of type 2 diabetes. PMID: 20625434
    16. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation PMID: 17273977
    17. Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. PMID: 17503335
    18. In fibroboasts, STRA6 transports retinol bidirectionally in an RBP4 dependent manner. PMID: 18316031
    19. study identifies an essential functional domain in STRA6 and a human polymorphism in this domain that leads to reduced vitamin A uptake activity PMID: 18387951
    20. This study explores the association of STRA6 and SKI genes in a cohort of subjects with anophthalmia and microphthalmia. PMID: 19112531
    21. Two novel STRA6 mutations in a patient with anophthalamia and diaphragmatic eventration are reported. PMID: 19213032
    22. Six novel mutations were identified in STRA6. PMID: 19309693

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Microphthalmia, syndromic, 9 (MCOPS9)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性:
    Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
  • 數據庫鏈接:

    HGNC: 30650

    OMIM: 601186

    KEGG: hsa:64220

    STRING: 9606.ENSP00000456609

    UniGene: Hs.24553



主站蜘蛛池模板: 欧美va天堂在线电影| 欧美另类又黄又爽的a片| 无线乱码一二三区免费看| 浴室人妻的情欲hd三级国产| 日韩av无码精品一二三区| 成人天堂婷婷青青视频在线观看| 亚洲gv猛男gv无码男同 | 午夜a理论片在线播放| 国产日韩精品视频无码 | 中文无码一区二区三区在线观看| 天堂中文最新版在线官网在线| 大学生久久香蕉国产线看观看| 亚洲一码二码三码精华液| 国产成人一区二区三区免费视频| 五月天精品视频在线观看| 欧美成人一区二区三区片免费| 久久久久久国产精品无码超碰| 无码av动漫精品一区二区免费| 欧美大香线蕉线伊人久久| 日本乱子伦一区二区三区| 黑人糟蹋人妻hd中文字幕| 中文文字幕文字幕亚洲色| 欧美 日韩 国产 另类 图片区| 欧美成人片在线观看| 色欲精品国产一区二区三区av| 一本色道久久东京热| 性欧美丰满熟妇xxxx性| 一出一进一爽一粗一大视频| av无码国产精品麻豆| 蜜桃麻豆www久久国产sex| 国产美女牲交视频| 亚洲人成网站观看在线播放| 日韩精品亚洲aⅴ在线影院| 欧美天天综合色影久久精品| 欧美xxxx做受欧美| 亚洲va在线va天堂xx xx| 精品国产自在精品国产精华天| 荫蒂被男人添的好舒服爽免费视频| 亚洲色18禁成人网站www| 日本欧美一区二区三区高清 | 在线观看国产一区二区三区|