在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

STRA6 Antibody, Biotin conjugated

  • 中文名稱:
    STRA6兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA866301LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STRA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STRA6
  • 別名:
    MCOPCB8 antibody; MCOPS9 antibody; PP14296 antibody; Stimulated by retinoic acid 6 homolog antibody; Stimulated by retinoic acid gene 6 protein homolog antibody; STRA6 antibody; STRA6_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Receptor for retinol uptake STRA6 protein (530-667AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid.
  • 基因功能參考文獻:
    1. Mutations in retinoic acid 6 gene (STRA6) have been reported in clinically diagnosed patients with MWS. Here we presented a case with MWS, who has characteristic findings of the syndrome as well as dextrocardia as an undescribed feature, and bilateral streak gonads which was described only in one patient previously. Molecular analysis showed a homozygous exonic missense mutation in the STRA6 gene. PMID: 30204971
    2. The knockdown of STRA6 slightly enhanced nodule formation at the late stage of osteoblast differentiation, and overexpression of STRA6 in ST2 cells enhanced adipocyte differentiation. PMID: 29067460
    3. these data demonstrate a key role of STRA6 and RBP4 in the maintenance of colon cancer self-renewal and that this pathway is an important link through which consumption of HFD contributes to colon carcinogenesis. PMID: 28689994
    4. this study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of type 2 diabetes mellitus(T2DM) while RARRES2 polymorphism could not predict the risk of T2DM PMID: 27446956
    5. A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly. PMID: 26373900
    6. These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers. PMID: 25237067
    7. Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6. PMID: 24223695
    8. STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells PMID: 24284421
    9. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. PMID: 23449393
    10. Analysis of FRAS1 and STRA6 mutations in the same family with eye anomalies. PMID: 22283518
    11. Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities. PMID: 22686418
    12. TTR blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling. PMID: 22826435
    13. STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin. PMID: 22665496
    14. STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS. PMID: 21901792
    15. SNPs in STRA6, gene coding the cell surface receptor for RBP4, were significantly associated with type 2 diabetes and further genetic and functional studies are required to understand and ascertain its role in the manifestation of type 2 diabetes. PMID: 20625434
    16. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation PMID: 17273977
    17. Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. PMID: 17503335
    18. In fibroboasts, STRA6 transports retinol bidirectionally in an RBP4 dependent manner. PMID: 18316031
    19. study identifies an essential functional domain in STRA6 and a human polymorphism in this domain that leads to reduced vitamin A uptake activity PMID: 18387951
    20. This study explores the association of STRA6 and SKI genes in a cohort of subjects with anophthalmia and microphthalmia. PMID: 19112531
    21. Two novel STRA6 mutations in a patient with anophthalamia and diaphragmatic eventration are reported. PMID: 19213032
    22. Six novel mutations were identified in STRA6. PMID: 19309693

    顯示更多

    收起更多

  • 相關疾病:
    Microphthalmia, syndromic, 9 (MCOPS9)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性:
    Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris.
  • 數據庫鏈接:

    HGNC: 30650

    OMIM: 601186

    KEGG: hsa:64220

    STRING: 9606.ENSP00000456609

    UniGene: Hs.24553



主站蜘蛛池模板: 97成人精品区在线播放| 国偷自产一区二区免费视频| 两个人日本www免费版| 亚洲日韩在线a视频在线观看| 日日碰狠狠躁久久躁9| 99久久99久久久精品齐齐| 天堂√最新版中文在线地址| 黑人狠狠的挺身进入| 亚洲婷婷五月激情综合app| 亚洲国产精品福利片在线观看| 最爽free性欧美人妖| 成年女人免费v片| 久久久99精品成人片| 少妇高潮大叫好爽| 欧美真人做爰在线观看| 中日av乱码一区二区三区乱码| 东京热人妻无码一区二区av| 综合精品欧美日韩国产在线| 爱情岛论坛网亚洲品质| 免费观看羞羞视频网站| 国产玉足脚交极品在线播放| 别揉我奶头~嗯~啊~一区二区三区| 午夜三级a三级三点在线观看| 国产精品人成视频免费999 | 国产sm重味一区二区三区| 亚洲va欧美va天堂v国产综合| 国产精品成人a区在线观看| 四虎亚洲精品成人a在线观看| 国产亚洲精品久久久久久彩霞| 中文字幕人妻熟女人妻| 西西人体44www大胆无码| 成人片黄网站a毛片免费观看| 97在线观看播放| 无码av波多野结衣久久| 2020最新国产在线不卡a| 欧美成aⅴ人高清免费观看| 国产无遮挡又黄又爽在线观看| 十八18禁国产精品www| 亚洲熟女精品中文字幕| 亚洲欧美成αⅴ人在线观看| 亚洲精品成a人在线观看|