在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SNX5 Antibody

SNX5 Antibody

  • 中文名稱：
    SNX5兔多克隆抗體
  • 貨號：
    CSB-PA287873
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA287873(SNX5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, Jurkat cells, Primary antibody: CSB-PA287873(SNX5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    0910001N05Rik antibody; 1810032P22Rik antibody; AU019504 antibody; D2Ertd52e antibody; FLJ10931 antibody; OTTHUMP00000030340 antibody; OTTHUMP00000062927 antibody; OTTMUSP00000003367 antibody; OTTMUSP00000003368 antibody; RP11-504H3.2 antibody; RP23-35E16.2 antibody; snoRNA MBI-43 antibody; SNX 5 antibody; SNX5 antibody; SNX5_HUMAN antibody; Sorting nexin 5 antibody; Sorting nexin-5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SNX5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent. Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. Plays a role in macropinocytosis.
  • 基因功能參考文獻：
    1. High SNX5 expression is associated with alphavirus infections. PMID: 29743363
    2. sorting nexin 5 (SNX5), a component of the retromer and part of the retrograde transport pathway, interacts with UL35 proteins. binding of UL35 proteins to SNX5 was required for efficient viral replication and for transport of the most abundant cytomegalovirus glycoprotein B to the cytoplasmic viral assembly center. PMID: 29444945
    3. The Chlamydia trachomatis IncE binding site is unique to human SNX5 and related family members SNX6 and SNX32. PMID: 28226239
    4. Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells PMID: 25825816
    5. internalization of agonist-activated D1R is regulated by both SNX5 and GRK4, and that SNX5 is critical to the recycling of the receptor to the plasma membrane PMID: 23195037
    6. Data indicate induction of caspase-2 by sorting nexin 5 (SNX5) in papillary thyroid carcinoma PMID: 22486813
    7. SNX5 is localized to a subdomain of the early endosomes and is recruited to the cell membrane following EGF stimulation. PMID: 15561769
    8. SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer PMID: 17148574
    9. DOCK180 regulates CI-MPR trafficking via SNX5 and this function is independent of its guanine nucleotide exchange factor activity toward Rac1 PMID: 18596235

    顯示更多

    收起更多

  • 亞細胞定位：
    Endosome. Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle.
  • 蛋白家族：
    Sorting nexin family
  • 數據庫鏈接：

    HGNC: 14969

    OMIM: 605937

    KEGG: hsa:27131

    STRING: 9606.ENSP00000366988

    UniGene: Hs.316890



主站蜘蛛池模板： 99er热精品视频| 国产欧美一区二区三区免费视频| 久久久国产精品麻豆a片| 在线精品自偷自拍无码| 内射后入在线观看一区| 欧美性猛交xxxx免费视频软件| 国产成人精品男人的天堂| 成人啪啪高潮不断观看| 97碰碰碰免费公开在线视频| 久久精品成人免费国产| 邻居少妇张开腿让我爽了一夜| 人妻老妇乱子伦精品无码专区| 国内自拍久久久久影院| 亚洲国产精品ⅴa在线播放| 国产人与zoxxxx另类| 亚洲国产成人无码av在线| 综合精品欧美日韩国产在线| 亚洲精品无码久久久久av麻豆| 他掀开裙子把舌头伸进去添视频| av无码欧洲亚洲电影网| 日本边添边摸边做边爱的网站| 亚洲婷婷五月综合狠狠爱| 欧美粗大猛烈老熟妇| 蜜臀av网站在线| 久久人人做人人爽人人av| 性一交一黄一片| 成人欧美日韩一区二区三区| 亚洲精品色无码av试看| 亚洲精品成人av观看| 欧美性xxxxx极品少妇直播| 久久婷婷五月综合97色一本一本| 在线看片免费人成视频久网| 免费无码黄动漫十八禁| 久久66热人妻偷产精品9| 一边吃奶一边做动态图| 免费无码毛片一区二三区| 欧洲熟妇色xxxx欧美老妇老头多毛 | 精品久久久久久无码中文野结衣| 亚洲成a人片在线观看高清| 美女人妻激情乱人伦| 亚洲日韩一中文字暮av|