在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SNX5 Antibody

SNX5 Antibody

  • 中文名稱：
    SNX5兔多克隆抗體
  • 貨號：
    CSB-PA045108
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA045108(SNX5 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, hepg2 cells, 293T cells, A549 cells, Primary antibody: CSB-PA045108(SNX5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    0910001N05Rik antibody; 1810032P22Rik antibody; AU019504 antibody; D2Ertd52e antibody; FLJ10931 antibody; OTTHUMP00000030340 antibody; OTTHUMP00000062927 antibody; OTTMUSP00000003367 antibody; OTTMUSP00000003368 antibody; RP11-504H3.2 antibody; RP23-35E16.2 antibody; snoRNA MBI-43 antibody; SNX 5 antibody; SNX5 antibody; SNX5_HUMAN antibody; Sorting nexin 5 antibody; Sorting nexin-5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SNX5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent. Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. Plays a role in macropinocytosis.
  • 基因功能參考文獻：
    1. High SNX5 expression is associated with alphavirus infections. PMID: 29743363
    2. sorting nexin 5 (SNX5), a component of the retromer and part of the retrograde transport pathway, interacts with UL35 proteins. binding of UL35 proteins to SNX5 was required for efficient viral replication and for transport of the most abundant cytomegalovirus glycoprotein B to the cytoplasmic viral assembly center. PMID: 29444945
    3. The Chlamydia trachomatis IncE binding site is unique to human SNX5 and related family members SNX6 and SNX32. PMID: 28226239
    4. Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells PMID: 25825816
    5. internalization of agonist-activated D1R is regulated by both SNX5 and GRK4, and that SNX5 is critical to the recycling of the receptor to the plasma membrane PMID: 23195037
    6. Data indicate induction of caspase-2 by sorting nexin 5 (SNX5) in papillary thyroid carcinoma PMID: 22486813
    7. SNX5 is localized to a subdomain of the early endosomes and is recruited to the cell membrane following EGF stimulation. PMID: 15561769
    8. SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer PMID: 17148574
    9. DOCK180 regulates CI-MPR trafficking via SNX5 and this function is independent of its guanine nucleotide exchange factor activity toward Rac1 PMID: 18596235

    顯示更多

    收起更多

  • 亞細胞定位：
    Endosome. Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle.
  • 蛋白家族：
    Sorting nexin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14969

    OMIM: 605937

    KEGG: hsa:27131

    STRING: 9606.ENSP00000366988

    UniGene: Hs.316890



主站蜘蛛池模板： 日日澡夜夜澡人人高潮| 久久国产色av免费观看| 四虎av永久在线精品免费观看 | 久久人妻内射无码一区三区| 少妇特黄a一区二区三区| 四虎国产精品永久入口| 国产又大又硬又粗| 人成午夜免费大片| 日躁夜躁狠狠躁2001| 久久久久亚洲精品男人的天堂| 内射人妻视频国内| 最新国产久免费视频在线观看| 思思久久精品一本到99热| 国产小屁孩cao大人免费| 理论片午午伦夜理片影院99| 亚洲乱亚洲乱少妇无码99p| 久久久久久亚洲精品成人| 不卡高清av手机在线观看| 在线观看片免费视频无码| 国产美女精品一区二区三区 | 202丰满熟女妇大| 日韩毛片在线视频x| 人人玩人人添人人澡超碰偷拍 | 77se77亚洲欧美在线| 正在播放熟妇群老熟妇456| 亚洲欧美综合区自拍另类| 国产乱人伦app精品久久| 国产性猛交普通话对白| 狠狠噜天天噜日日噜色综合| 夜夜夜夜猛噜噜噜噜噜| 国内老熟妇对白hdxxxx| 亚洲国产精品高清久久久| 亚洲中国最大av网站| 色翁荡熄又大又硬又粗又动态图| 日本丰满白嫩大屁股ass| 日本精品αv中文字幕| 国语少妇高潮对白在线| 黑人巨大精品欧美一区二区| 亚洲精品国产成人99久久6 | 亚洲线精品一区二区三区影音先锋| 色噜噜一区二区三区|