在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SNX3 Antibody

  • 中文名稱:
    SNX3兔多克隆抗體
  • 貨號:
    CSB-PA01324A0Rb
  • 規(guī)格:
    ¥440
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SNX3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Grd19 antibody; MCOPS8 antibody; MGC151262 antibody; MGC151266 antibody; MGC17570 antibody; OTTHUMP00000016941 antibody; OTTHUMP00000046475 antibody; OTTHUMP00000046476 antibody; Protein SDP3 antibody; SDP3 antibody; SNX3 antibody; SNX3_HUMAN antibody; SNX3A antibody; Sorting nexin 3 antibody; Sorting nexin 3A antibody; Sorting nexin-3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Sorting nexin-3 protein (3-162AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,SNX3 Antibody (CSB-PA01324A0Rb),的標記方式是Non-conjugated。對于SNX3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA01324B0Rb SNX3 Antibody, HRP conjugated ELISA
    FITC CSB-PA01324C0Rb SNX3 Antibody, FITC conjugated
    Biotin CSB-PA01324D0Rb SNX3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.
  • 基因功能參考文獻:
    1. SNX3-retromer complex regulates the surface expression and function of PC1 and PC2 PMID: 28620080
    2. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 & VPS35 subunits of retromer, sorting nexin SNX3, & recycling signal from the divalent cation transporter DMT1-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 & SNX3; shows cooperative interactions among the VPS subunits, SNX3 & cargo that couple signal-recognition to membrane recruitment. PMID: 27889239
    3. Data show that over-expression of sorting nexin 3 (hSNX3) alters the morphology of colon cancer SW620 cells, but hardly affects cell migration. PMID: 26271979
    4. SNX3 negatively regulates phagocytosis in DC possibly by modulating recruitment of essential PI3P lipid-binding proteins of the phagocytic pathways, such as EEA1, to phagosomal membranes. PMID: 23237080
    5. This study found that four significant SNX3 SNPs in the discovery sample were replicated in a community-based sample of Israeli-Arabs PMID: 22673115
    6. SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the early/sorting endosome PMID: 22159558
    7. SNX3 plays a significant role in regulating the maturation of Salmonella containing vacuoles. PMID: 20482551
    8. Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype PMID: 12471201
    9. we cannot exclude the possibility that deletions at SNX3 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions PMID: 17655765
    10. Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor degradation. PMID: 18767904

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Microphthalmia, syndromic, 8 (MCOPS8)
  • 亞細胞定位:
    Early endosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族:
    Sorting nexin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11174

    OMIM: 601349

    KEGG: hsa:8724

    STRING: 9606.ENSP00000230085

    UniGene: Hs.12102



主站蜘蛛池模板: 亚洲男男无套gv大学生| 久久这里只精品国产免费9| 在线观看国产午夜福利片| 和黑人邻居中文字幕在线| 无套内谢孕妇毛片免费看| 情人伊人久久综合亚洲 | 风流老熟女一区二区三区| 久久综合九色综合欧美狠狠| 动漫av纯肉无码av电影网| 正在播放国产剧情亂倫| 内射囯产旡码丰满少妇| 高潮内射免费看片| 亚洲韩国日本高清一区| 欧美成人精品第一区| 国产suv精品一区二区| 国产乱码人妻一区二区三区四区| 国产精品a国产精品a手机版| 国产成人亚洲精品无码青青草原| 午夜日本大胆裸艺术| 射死你天天日| 亚洲 另类 日韩 制服 无码| 欧美精品18videosex性欧| 亚洲爱婷婷色婷婷五月| 人妻教师痴汉电车波多野结衣 | 国产人妻xxxx精品hd| 97久久人人超碰超碰窝窝| 国产l精品国产亚洲区久久| 免费无码成人av在线播| 国产精品无码a∨麻豆| 国产亚洲精品久久久久久久| 亚洲日韩成人性av网站| 亚洲精品一区二区国产精华液| 蜜臀av性久久久久蜜臀aⅴ麻豆| 久久久精品波多野结衣| 国产精品久久无码不卡| 少妇无码av无码专线区大牛影院| 中文无码乱人伦中文视频在线| 欧美破苞系列二十三| 亚洲a∨精品永久无码| 一区二区传媒有限公司| 久久人妻无码一区二区|