在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SNX3 Antibody

SNX3 Antibody

  • 中文名稱：
    SNX3兔多克隆抗體
  • 貨號：
    CSB-PA983441
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA983441(SNX3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA983441(SNX3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cells, lovo cells, hela cells, Primary antibody: CSB-PA983441(SNX3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Grd19 antibody; MCOPS8 antibody; MGC151262 antibody; MGC151266 antibody; MGC17570 antibody; OTTHUMP00000016941 antibody; OTTHUMP00000046475 antibody; OTTHUMP00000046476 antibody; Protein SDP3 antibody; SDP3 antibody; SNX3 antibody; SNX3_HUMAN antibody; SNX3A antibody; Sorting nexin 3 antibody; Sorting nexin 3A antibody; Sorting nexin-3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SNX3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.
  • 基因功能參考文獻(xiàn)：
    1. SNX3-retromer complex regulates the surface expression and function of PC1 and PC2 PMID: 28620080
    2. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 & VPS35 subunits of retromer, sorting nexin SNX3, & recycling signal from the divalent cation transporter DMT1-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 & SNX3; shows cooperative interactions among the VPS subunits, SNX3 & cargo that couple signal-recognition to membrane recruitment. PMID: 27889239
    3. Data show that over-expression of sorting nexin 3 (hSNX3) alters the morphology of colon cancer SW620 cells, but hardly affects cell migration. PMID: 26271979
    4. SNX3 negatively regulates phagocytosis in DC possibly by modulating recruitment of essential PI3P lipid-binding proteins of the phagocytic pathways, such as EEA1, to phagosomal membranes. PMID: 23237080
    5. This study found that four significant SNX3 SNPs in the discovery sample were replicated in a community-based sample of Israeli-Arabs PMID: 22673115
    6. SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the early/sorting endosome PMID: 22159558
    7. SNX3 plays a significant role in regulating the maturation of Salmonella containing vacuoles. PMID: 20482551
    8. Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype PMID: 12471201
    9. we cannot exclude the possibility that deletions at SNX3 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions PMID: 17655765
    10. Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor degradation. PMID: 18767904

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Microphthalmia, syndromic, 8 (MCOPS8)
  • 亞細(xì)胞定位：
    Early endosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Sorting nexin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11174

    OMIM: 601349

    KEGG: hsa:8724

    STRING: 9606.ENSP00000230085

    UniGene: Hs.12102



主站蜘蛛池模板： 亚洲成年看片在线观看| 日韩国产丝袜人妻一二区| 亚洲黑人巨大videos| 国产成人剧情av麻豆果冻| 国产乱人伦av在线a最新| 欧美三级在线播放| 国产福利一区二区三区在线观看| 色偷一区国产精品| 国内无遮挡18禁无码网站免费| 精品少妇无码一区二区三批| 影音先锋亚洲成aⅴ人在| 国产肥熟女视频一区二区三区 | 中文精品一卡2卡3卡4卡国色| 国产一区丝袜高跟鞋| 久久久精品94久久精品| 伊人久久大香线蕉亚洲五月天| 欧美又大粗又爽又黄大片视频 | 国产男女免费完整视频网页| 丰满人妻av无码一区二区三区| 隔壁老王国产在线精品| 全球成人中文在线| 新香蕉少妇视频网站| 日本添下边视频全过程| 日韩国产高清一区二区| 国产果冻豆传媒麻婆| 久久av无码精品人妻出轨 | 精品国产午夜肉伦伦影院| 亚洲国产成av人天堂无码| 免费的污污的网站在线观看| 无码人妻av一区二区三区蜜臀| 人与禽交av在线播放| 久久久av男人的天堂| 乱人伦中文无码视频| 无码国产精品一区二区高潮| 亚洲精品久久久一二三区| 热re99久久6国产精品免费| 中文精品久久久久人妻不卡| 国产精品久久福利网站| 麻豆国产原创视频在线播放| 亚洲欧美在线观看| 欧美巨鞭大战丰满少妇|