在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SNX3 Antibody

  • 中文名稱:
    SNX3兔多克隆抗體
  • 貨號:
    CSB-PA291069
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, using SNX3 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SNX3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human SNX3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.
  • 基因功能參考文獻:
    1. SNX3-retromer complex regulates the surface expression and function of PC1 and PC2 PMID: 28620080
    2. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 & VPS35 subunits of retromer, sorting nexin SNX3, & recycling signal from the divalent cation transporter DMT1-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 & SNX3; shows cooperative interactions among the VPS subunits, SNX3 & cargo that couple signal-recognition to membrane recruitment. PMID: 27889239
    3. Data show that over-expression of sorting nexin 3 (hSNX3) alters the morphology of colon cancer SW620 cells, but hardly affects cell migration. PMID: 26271979
    4. SNX3 negatively regulates phagocytosis in DC possibly by modulating recruitment of essential PI3P lipid-binding proteins of the phagocytic pathways, such as EEA1, to phagosomal membranes. PMID: 23237080
    5. This study found that four significant SNX3 SNPs in the discovery sample were replicated in a community-based sample of Israeli-Arabs PMID: 22673115
    6. SNX3 and SNX5 play essential roles in the aspirin-mediated accumulation of endocytosed-TfnR at the early/sorting endosome PMID: 22159558
    7. SNX3 plays a significant role in regulating the maturation of Salmonella containing vacuoles. PMID: 20482551
    8. Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype PMID: 12471201
    9. we cannot exclude the possibility that deletions at SNX3 may underlie MMEP, given that sequencing is unable to distinguish between homozygosity across loci versus large deletions PMID: 17655765
    10. Data show that Hrs is essential for lysosomal targeting but not multivesicular body biogenesis and transport to late endosomes, while SNX3 is required for multivesicular body formation, but not for EGF receptor degradation. PMID: 18767904

    顯示更多

    收起更多

  • 相關疾病:
    Microphthalmia, syndromic, 8 (MCOPS8)
  • 亞細胞定位:
    Early endosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族:
    Sorting nexin family
  • 數據庫鏈接:

    HGNC: 11174

    OMIM: 601349

    KEGG: hsa:8724

    STRING: 9606.ENSP00000230085

    UniGene: Hs.12102



主站蜘蛛池模板: 日本公与熄乱理在线播放| 天堂在线观看www| 亚洲中文字幕无码日韩| 色偷拍 自怕 亚洲 10p| 国产超碰人人做人人爽av动图| 亚洲成av人片高潮喷水| 亚洲熟妇av一区二区三区| 九九九免费观看视频| 伊人久久精品在热线热| 丰满人妻无奈张开双腿av| 性高朝久久久久久久久久| 日本熟妇人妻中出| 成av人片在线观看www| 久久综合a∨色老头免费观看| 在线播放国产麻豆va剧情| 欧美日韩在线视频一区| 亚洲精品成人片在线观看精品字幕 | 欧美亚洲人成网站在线观看| 无码av专区丝袜专区| 精品午夜福利1000在线观看| 成人亚洲精品久久久久| 香蕉久久国产超碰青草| 久久人人97超碰超国产| 国色天香社区视频| 男受被做哭激烈娇喘gv视频| 亚洲www啪成人一区二区| 亚洲一线产区二线产区分布| 最近中文av字幕在线中文| 亚欧美无遮挡hd高清在线视频 | 国产午夜成人无码免费看不卡| 鲁鲁夜夜天天综合视频| 人人摸人人搞人人透| 99久久久无码国产精品性| 欧美黑人xxxx又粗又长| 国产精品亚洲第一区在线观看| 国产猛烈高潮尖叫视频免费| 国产精品久久久久久久久久久久午衣片 | 亚洲欧美国产va在线播放| 国产av国片精品| 欧美老妇牲交videos| 国产在线无码播放不卡视频|