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SLC6A19 Antibody

  • 中文名稱：
    SLC6A19兔多克隆抗體
  • 貨號：
    CSB-PA731656LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA731656LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC6A19 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SLC6A19 antibody; B0AT1 antibody; Sodium-dependent neutral amino acid transporter B(0)AT1 antibody; Solute carrier family 6 member 19 antibody; System B(0) neutral amino acid transporter AT1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium-dependent neutral amino acid transporter B(0)AT1 protein (326-413AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SLC6A19 Antibody (CSB-PA731656LA01HU)，的標記方式是Non-conjugated。對于SLC6A19 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA731656LB01HU SLC6A19 Antibody, HRP conjugated ELISA
    FITC CSB-PA731656LC01HU SLC6A19 Antibody, FITC conjugated
    Biotin CSB-PA731656LD01HU SLC6A19 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.
  • 基因功能參考文獻：
    1. SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes. PMID: 25534429
    2. PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells. PMID: 23234856
    3. JAK2 up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 expressing cells. PMID: 21964291
    4. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts. PMID: 20883558
    5. A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder. PMID: 20399395
    6. We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes. PMID: 15286788
    7. One mutation, the D173N allele, is present in 42% of Hartnup chromosomes from apparently unrelated families from both Australia and North America. PMID: 17555458
    8. Hartnup disorder is allelically heterogeneous with two mutated SLC6A19 allele. PMID: 18484095
    9. These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension. PMID: 18671945
    10. Suggest that amino acid transporters B(0)AT1 and b(0,+)AT are involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells. PMID: 19322909
    11. novel homozygous mutation of G284R in the transmembrane domain of the SLC6A19 transporter found in the proband, with typical dermatologic and neurologic manifestations and increased levels of urinary neutral amino acids PMID: 19335424
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 18671945

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  • 相關疾病：
    Hartnup disorder (HND); Hyperglycinuria (HG); Iminoglycinuria (IG)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A19 subfamily
  • 組織特異性：
    Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus,
  • 數據庫鏈接：

    HGNC: 27960

    OMIM: 138500

    KEGG: hsa:340024

    STRING: 9606.ENSP00000305302

    UniGene: Hs.481478



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