在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC6A19 Antibody, FITC conjugated

  • 中文名稱:
    SLC6A19兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA731656LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC6A19 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC6A19 antibody; B0AT1 antibody; Sodium-dependent neutral amino acid transporter B(0)AT1 antibody; Solute carrier family 6 member 19 antibody; System B(0) neutral amino acid transporter AT1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sodium-dependent neutral amino acid transporter B(0)AT1 protein (326-413AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.
  • 基因功能參考文獻:
    1. SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes. PMID: 25534429
    2. PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells. PMID: 23234856
    3. JAK2 up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 expressing cells. PMID: 21964291
    4. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts. PMID: 20883558
    5. A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder. PMID: 20399395
    6. We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes. PMID: 15286788
    7. One mutation, the D173N allele, is present in 42% of Hartnup chromosomes from apparently unrelated families from both Australia and North America. PMID: 17555458
    8. Hartnup disorder is allelically heterogeneous with two mutated SLC6A19 allele. PMID: 18484095
    9. These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension. PMID: 18671945
    10. Suggest that amino acid transporters B(0)AT1 and b(0,+)AT are involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells. PMID: 19322909
    11. novel homozygous mutation of G284R in the transmembrane domain of the SLC6A19 transporter found in the proband, with typical dermatologic and neurologic manifestations and increased levels of urinary neutral amino acids PMID: 19335424
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 18671945

    顯示更多

    收起更多

  • 相關疾病:
    Hartnup disorder (HND); Hyperglycinuria (HG); Iminoglycinuria (IG)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A19 subfamily
  • 組織特異性:
    Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus,
  • 數據庫鏈接:

    HGNC: 27960

    OMIM: 138500

    KEGG: hsa:340024

    STRING: 9606.ENSP00000305302

    UniGene: Hs.481478



主站蜘蛛池模板: 18禁亚洲深夜福利人口| 日韩av中文无码影院| 久久国内精品自在自线图片| 日韩99在线 | 中文| 国产成人三级在线视频网站观看| 中文字幕精品一区二区2021年| 成人动漫综合网| 欧美性受xxxx黑人xyx性爽| 乱码午夜-极品国产内射| 日本熟妇色一本在线观看| 亚洲国产精品成人精品无码区| 在线观看片免费视频无码| 99久久人妻无码精品系列蜜桃| 成人h视频在线观看| 男女又色又爽又爽视频| 亚洲 欧美 自拍 美腿 卡通| 亚洲欧美日韩国产精品一区| 国产精品熟妇一区二区三区四区| 亚洲综合无码久久精品综合| 女人被狂躁c到高潮喷水电影| 国精品午夜福利视频| av第一福利网站| 欧美xxxxx精品| 爽爽精品dvd蜜桃成熟时电影院| 日产乱码一区二区三区在线 | 亚洲va欧美va国产va综合| 免费国精产品wnw2544| 国产亚洲精品久久久久久大师 | 亚洲人色婷婷成人网站在线观看| 亚洲日韩av在线观看| 香蕉久久一区二区三区啪啪| 欧洲熟妇色xxxxx视频| 国产成av人片久青草影院| 亚洲第一页综合图片自拍| 无码国产精成人午夜视频一区二区 | 国产精品久久久久久| 日韩高清成片免费视频| 乱码国产丰满人妻www| 99精品久久毛片a片| 国产产无码乱码精品久久鸭| 国产白丝精品爽爽久久久久久蜜臀 |