在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC6A19 Antibody

  • 中文名稱:
    SLC6A19兔多克隆抗體
  • 貨號:
    CSB-PA129068
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA129068(SLC6A19 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SLC6A19 antibody; B0AT1 antibody; Sodium-dependent neutral amino acid transporter B(0)AT1 antibody; Solute carrier family 6 member 19 antibody; System B(0) neutral amino acid transporter AT1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human SLC6A19
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity.
  • 基因功能參考文獻:
    1. SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes. PMID: 25534429
    2. PKB/Akt up-regulates SLC6A19 activity, which may foster amino acid uptake into PKB/Akt-expressing epithelial and tumor cells. PMID: 23234856
    3. JAK2 up-regulates SLC6A19 activity which may foster amino acid uptake into JAK2 expressing cells. PMID: 21964291
    4. Average loss of solute carrier expression was similar in acute tubular necrosis (77%) and T cell-mediated rejection (75%) with high correlation of individual transcripts. PMID: 20883558
    5. A novel SLC6A19 gene mutation is associated with late-onset seizures in a Korean patient with Hartnup disorder. PMID: 20399395
    6. We identified six mutations in SLC6A19 that cosegregated with disease in the predicted recessive manner, with most affected individuals being compound heterozygotes. PMID: 15286788
    7. One mutation, the D173N allele, is present in 42% of Hartnup chromosomes from apparently unrelated families from both Australia and North America. PMID: 17555458
    8. Hartnup disorder is allelically heterogeneous with two mutated SLC6A19 allele. PMID: 18484095
    9. These findings suggest that the rare SLC6A19-MS7 allele may be a risk factor for hypertension. PMID: 18671945
    10. Suggest that amino acid transporters B(0)AT1 and b(0,+)AT are involved in the reabsorption of L-citrulline in the kidney, at least in part, by mediating the apical membrane transport of L-citrulline in renal tubule cells. PMID: 19322909
    11. novel homozygous mutation of G284R in the transmembrane domain of the SLC6A19 transporter found in the proband, with typical dermatologic and neurologic manifestations and increased levels of urinary neutral amino acids PMID: 19335424
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 18671945

    顯示更多

    收起更多

  • 相關疾病:
    Hartnup disorder (HND); Hyperglycinuria (HG); Iminoglycinuria (IG)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A19 subfamily
  • 組織特異性:
    Robust expression in kidney and small intestine, with minimal expression in pancreas. Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus,
  • 數據庫鏈接:

    HGNC: 27960

    OMIM: 138500

    KEGG: hsa:340024

    STRING: 9606.ENSP00000305302

    UniGene: Hs.481478



主站蜘蛛池模板: 99精品国产一区二区| 中文字幕无码精品亚洲35| 俺也来俺也去俺也射| 一区二区三区在线 | 网站| 亚洲精品第一国产综合精品| 欧美黑人巨大videos精品男男| 天堂亚洲国产中文在线| 成人婷婷网色偷偷亚洲男人的天堂 | 吃奶摸下的激烈视频| 国产丝袜肉丝视频在线| 亚洲乱色熟女一区二区三区丝袜| 久久精品麻豆日日躁夜夜躁| 囯产精品久久久久久久久久妞妞| 国产白嫩护士在线播放| 日本乱妇乱子视频| 午夜dj在线观看免费视频| 亚洲午夜久久久久久久久电影网| 丁香五月激情综合色婷婷| 久久99日韩国产精品久久99 | 国产9 9在线 | 欧洲| 丁香花在线影院观看在线播放| 欧美极品少妇性运交| 欧产日产国产精品| 国产良妇出轨视频在线观看| 亚洲国产精品无码久久久久高潮| 亚洲欧美日本国产专区一区| 中文字幕亂倫免賛視頻| 一本色综合亚洲精品蜜桃冫| 失禁大喷潮在线播放| 色欲精品国产一区二区三区av| 丁香五月缴情在线| 欧美 日韩 国产 另类 图片区 | 蜜臀av网站在线| 亚洲一区二区av在线观看| 亚洲夂夂婷婷色拍ww47| 无码人妻aⅴ一区二区三区有奶水| 人妻丰满熟妇av无码处处不卡| 内射人妻无码色ab麻豆| 丰满爆乳无码一区二区三区| 亚洲热无码av一区二区东京热av| 97婷婷狠狠成为人免费视频|