在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SIPA1 Antibody

SIPA1 Antibody

  • 中文名稱：
    SIPA1兔多克隆抗體
  • 貨號：
    CSB-PA021330LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HL60 whole cell lysate
      All lanes: SIPA1 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 112 kDa
      Observed band size: 130 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021330LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA021330LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021330LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SIPA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GTPase activating protein Spa 1 antibody; GTPase-activating protein Spa-1 antibody; MGC102688 antibody; MGC17037 antibody; p130 SPA-1 antibody; p130 SPA1 antibody; Signal induced proliferation associated 1 antibody; Signal induced proliferation associated gene 1 antibody; Signal induced proliferation associated protein 1 antibody; Signal-induced proliferation-associated protein 1 antibody; SIPA 1 antibody; Sipa-1 antibody; Sipa1 antibody; SIPA1_HUMAN antibody; Spa1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal-induced proliferation-associated protein 1 protein (759-927AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SIPA1 Antibody (CSB-PA021330LA01HU)，的標記方式是Non-conjugated。對于SIPA1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA021330LB01HU SIPA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA021330LC01HU SIPA1 Antibody, FITC conjugated
    Biotin CSB-PA021330LD01HU SIPA1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.
  • 基因功能參考文獻：
    1. SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7. PMID: 28237246
    2. Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density. PMID: 28362978
    3. results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis PMID: 26901824
    4. Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression. PMID: 25352027
    5. nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling. PMID: 24704834
    6. BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID: 24260471
    7. This meta-analysis suggests that rs746429 is associated with the risk of breast cancer. PMID: 24006220
    8. SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors. PMID: 23771732
    9. Polymorphism in Sipa1 promoter gene is associated with lung cancer. PMID: 23661532
    10. Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). PMID: 23358895
    11. SIPA1 expression is increased in human colorectal cancer. PMID: 22990111
    12. In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion. PMID: 19906411
    13. Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. PMID: 15456879
    14. SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer. PMID: 16563182
    15. SPA1 regulates the maintenance and differentiation of embryonic stem cells. PMID: 18033671
    16. it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia PMID: 18492118
    17. Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival PMID: 19089925
    18. SIPA1 SNP rs3741378 was associated with increased breast cancer incidence. PMID: 19765277

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
  • 組織特異性：
    Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
  • 數據庫鏈接：

    HGNC: 10885

    OMIM: 602180

    KEGG: hsa:6494

    STRING: 9606.ENSP00000377771

    UniGene: Hs.530477



主站蜘蛛池模板： 成人亚洲欧美在线观看| 久久99热只有频精品8| 蜜臀精品无码av在线播放| 国产a线视频播放| 国产白袜脚足j棉袜在线观看| 爆乳高潮喷水无码正在播放| 色偷偷av男人的天堂| 欧美亚洲日韩不卡在线在线观看| 无码高潮又爽又黄a片软件| 国产综合内射日韩久| 人妻影音先锋啪啪av资源| 女人裸体做爰免费视频| 国产精品福利一区二区久久| 又黄又粗又爽免费观看| 国产一区二区女内射| 丰满少妇大力进入| 一本大道在线观看无码一区| 99久久国产综合精品swag | 国产久热精品无码激情| 四虎精品免费永久免费视频| 欧美成人精品福利视频| 久久无码人妻一区二区三区| 国产性夜夜春夜夜爽免费下载 | 色噜噜噜亚洲男人的天堂| 亚洲国产一区二区三区在观看| 国产口爆吞精在线视频2020版| 久久综合久中文字幕青草| 日韩a毛片免费观看| 波多野结衣在线播放| 亚洲情综合五月天| 人成午夜免费视频无码| 美女扒开奶罩露出奶头视频网站 | 国产成人a亚洲精v品无码| 亚洲精品成人av在线| 97国产揄拍国产精品人妻| 夜夜爽夜夜叫夜夜高潮漏水| 国产suv精品一区二区33| 亚洲综合欧美在线一区在线播放| 成人区精品一区二区不卡| 中年熟妇的大黑p| 无码av免费网站|