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  4. Recombinant Human Signal-induced proliferation-associated protein 1 (SIPA1), partial

Recombinant Human Signal-induced proliferation-associated protein 1 (SIPA1), partial

  • 中文名稱：
    人SIPA1重組蛋白
  • 貨號：
    CSB-YP822213HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SIPA1重組蛋白
  • 貨號：
    CSB-EP822213HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SIPA1重組蛋白
  • 貨號：
    CSB-EP822213HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SIPA1重組蛋白
  • 貨號：
    CSB-BP822213HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SIPA1重組蛋白
  • 貨號：
    CSB-MP822213HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GTPase activating protein Spa 1; GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; p130 SPA1; Signal induced proliferation associated 1; Signal induced proliferation associated gene 1; Signal induced proliferation associated protein 1; Signal-induced proliferation-associated protein 1; SIPA 1; Sipa-1; Sipa1; SIPA1_HUMAN; Spa1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.
  • 基因功能參考文獻：
    1. SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7. PMID: 28237246
    2. Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density. PMID: 28362978
    3. results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis PMID: 26901824
    4. Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression. PMID: 25352027
    5. nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling. PMID: 24704834
    6. BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID: 24260471
    7. This meta-analysis suggests that rs746429 is associated with the risk of breast cancer. PMID: 24006220
    8. SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors. PMID: 23771732
    9. Polymorphism in Sipa1 promoter gene is associated with lung cancer. PMID: 23661532
    10. Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). PMID: 23358895
    11. SIPA1 expression is increased in human colorectal cancer. PMID: 22990111
    12. In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion. PMID: 19906411
    13. Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. PMID: 15456879
    14. SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer. PMID: 16563182
    15. SPA1 regulates the maintenance and differentiation of embryonic stem cells. PMID: 18033671
    16. it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia PMID: 18492118
    17. Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival PMID: 19089925
    18. SIPA1 SNP rs3741378 was associated with increased breast cancer incidence. PMID: 19765277

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  • 亞細胞定位：
    Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
  • 組織特異性：
    Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
  • 數據庫鏈接：

    HGNC: 10885

    OMIM: 602180

    KEGG: hsa:6494

    STRING: 9606.ENSP00000377771

    UniGene: Hs.530477



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