在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SIPA1 Antibody

SIPA1 Antibody

  • 中文名稱：
    SIPA1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA948911
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA948911(SIPA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA948911(SIPA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GTPase activating protein Spa 1 antibody; GTPase-activating protein Spa-1 antibody; MGC102688 antibody; MGC17037 antibody; p130 SPA-1 antibody; p130 SPA1 antibody; Signal induced proliferation associated 1 antibody; Signal induced proliferation associated gene 1 antibody; Signal induced proliferation associated protein 1 antibody; Signal-induced proliferation-associated protein 1 antibody; SIPA 1 antibody; Sipa-1 antibody; Sipa1 antibody; SIPA1_HUMAN antibody; Spa1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SIPA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression.
  • 基因功能參考文獻(xiàn)：
    1. SIPA1 promotes oral squamous cell carcinoma metastasis by regulating the ITGB1 and MMP7. PMID: 28237246
    2. Study shows that SIPA1 mRNA and protein expression are down-regulated in gastric cancer cells and correlate with tumor grading, invasion and lymph node metastasis as well as higher expression of VEGFA. Low SIPA1 levels in gastric cancer may then accelerate tumor development and progression by promoting VEGFA expression to increase vascular density. PMID: 28362978
    3. results suggest that SIPA1 and RRP1B germline polymorphisms are important for breast cancer prognosis PMID: 26901824
    4. Our results indicate, for the first time, that the SIPA1 -313A>G may have a prognostic role in unresected NSCLC making it a potential predictor of poor survival due to earlier progression. PMID: 25352027
    5. nuclear SIPA1 contributes to breast cancer cell invasion through the regulation of integrin beta1 signaling. PMID: 24704834
    6. BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane. PMID: 24260471
    7. This meta-analysis suggests that rs746429 is associated with the risk of breast cancer. PMID: 24006220
    8. SIPA1 SNPs, rs746429 and rs2306364, were associated with decreased risk of triple-negative breast tumors. PMID: 23771732
    9. Polymorphism in Sipa1 promoter gene is associated with lung cancer. PMID: 23661532
    10. Patients with metastatic breast cancer with SIPA1 545 T/T genotype had a significantly worse overall survival than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). PMID: 23358895
    11. SIPA1 expression is increased in human colorectal cancer. PMID: 22990111
    12. In this case-control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases and in MMP9 after controlling for stage and lymphvascular space invasion. PMID: 19906411
    13. Data identif a Rap GTPase-activating protein, signal-induced proliferation-associated protein 1 (SPA-1), as a factor that interacts with Brd4. PMID: 15456879
    14. SIPA1 germline polymorphisms are associated with aggressive disease behavior in breast cancer. PMID: 16563182
    15. SPA1 regulates the maintenance and differentiation of embryonic stem cells. PMID: 18033671
    16. it is unlikely that SIPA1 plays a pathogenetic role in the development of juvenile myelomonocytic leukemia PMID: 18492118
    17. Our results do not support a relationship between SIPA1 polymorphisms and breast cancer risk or subsequent survival PMID: 19089925
    18. SIPA1 SNP rs3741378 was associated with increased breast cancer incidence. PMID: 19765277

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
  • 組織特異性：
    Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10885

    OMIM: 602180

    KEGG: hsa:6494

    STRING: 9606.ENSP00000377771

    UniGene: Hs.530477



主站蜘蛛池模板： 无码任你躁久久久久久| 无遮挡裸体免费视频尤物| 中文字幕人成乱码在线观看| 妺妺窝人体色www在线小说| 亚洲αⅴ无码乱码在线观看性色| k频道国产在线观看| 亚洲欧美日韩成人综合一区| 久久中文字幕乱码久久午夜| 永久免费无码av在线网站| 久久经精品久久精品免费观看| 亚洲va中文字幕无码毛片| 性猛交ⅹxxx富婆视频| 狠狠躁日日躁夜夜躁2022麻豆| av无码国产在线观看岛国| 亚洲精品乱码一区二区三区| 亚洲国产av导航第一福利网| 在线视频观看免费视频18| 99久久久无码国产精品6| 久久久免费精品re6| 亚洲成a×人片在线观看| 精品无码久久久久国产电影| 久久精品国产亚洲αv忘忧草| 中文字幕人妻色偷偷久久| 亚洲精品国产品国语在线| 亚洲日韩成人性av网站| 人人人插人人费| 黑人巨大av在线播放无码| 国产成人一区二区三区| 久久精品无码一区二区三区| 亚洲成a人v在线蜜臀| 精品露脸国产偷人在视频| 岛国av动作片在线观看| 中文字幕无码中文字幕有码| 男人边吻奶边挵进去视频| 成熟老妇女毛茸茸的做性| 大地资源中文在线观看官网第二页| 性猛交ⅹxxx富婆视频| 国产高潮流白浆免费观看| 正在播放酒店约少妇高潮| 亚洲人成网网址在线看| 真人抽搐一进一出gif|