在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIK1 Antibody

  • 中文名稱:
    SIK1兔多克隆抗體
  • 貨號(hào):
    CSB-PA021321GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SIK1
  • 別名:
    KID2 antibody; MSK antibody; myocardial SNF1 like kinase antibody; QIK antibody; Qin-induced kinase antibody; Salt inducible kinase 1 antibody; Salt-inducible protein kinase 1 antibody; Serine threonine protein kinase SNF1 like kinase 1 antibody; Serine threonine protein kinase SNF1LK antibody; Serine/threonine-protein kinase SIK1 antibody; Serine/threonine-protein kinase SNF1-like kinase 1 antibody; Serine/threonine-protein kinase SNF1LK antibody; SIK-1 antibody; SIK1 antibody; SIK1_HUMAN antibody; SNF1 like kinase antibody; Snf1lk antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Human SIK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.
  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 30 (EIEE30)
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Note=Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, AMPK subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11142

    OMIM: 605705

    KEGG: hsa:102724428

    STRING: 9606.ENSP00000270162

    UniGene: Hs.282113



主站蜘蛛池模板: 国产麻豆md传媒视频| 亚洲在av极品无码天堂手机版| 国产极品美女到高潮无套| 在线观看高清黄网站观看| 好疼太大了太粗太长了视频| 欧美不卡一区二区三区| 国产精品无码免费专区午夜| 国产日产欧产精品精品| 日本一区二区三区不卡免费| 欧美日产成人高清视频| 性一交一乱一乱一视频| 久久婷婷五月综合色丁香| 国产精品爱啪在线播放| 双乳奶水饱满少妇呻吟免费看| 国产亚洲日韩在线a不卡| 久久久久国产a免费观看rela| 久久综合色之久久综合| av狼友无码国产在线观看| 无码一区二区三区av免费蜜桃| 免费精品国产自在| 中国无码人妻丰满熟妇啪啪软件| 男人av无码天堂| 蜜臀精品国产高清在线观看| 日本www网站色情乱码| 国产特级毛片aaaaaaa高清| 久久中文字幕人妻av熟女| 日本韩国的免费观看视频| 亚洲精品少妇一区二区| 欧美与黑人午夜性猛交久久久 | 真人做人试看60分钟免费视频 | 成人精品v视频在线| 欧美丰满熟妇bbbbbb| 色老久久精品偷偷鲁| 肉感饱满中年熟妇日本| 少妇极品熟妇人妻200片| 乱人伦中文字幕成人网站在线| 西西444www无码大胆| 美女粉嫩饱满的一线天mp4| 野外亲子乱子伦视频丶 | 国产精品一区二区av片| 丰满少妇大力进入|