在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIK1 Antibody

  • 中文名稱(chēng):
    SIK1兔多克隆抗體
  • 貨號(hào):
    CSB-PA011961
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA011961(SIK1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA011961(SIK1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SIK1
  • 別名:
    KID2 antibody; MSK antibody; myocardial SNF1 like kinase antibody; QIK antibody; Qin-induced kinase antibody; Salt inducible kinase 1 antibody; Salt-inducible protein kinase 1 antibody; Serine threonine protein kinase SNF1 like kinase 1 antibody; Serine threonine protein kinase SNF1LK antibody; Serine/threonine-protein kinase SIK1 antibody; Serine/threonine-protein kinase SNF1-like kinase 1 antibody; Serine/threonine-protein kinase SNF1LK antibody; SIK-1 antibody; SIK1 antibody; SIK1_HUMAN antibody; SNF1 like kinase antibody; Snf1lk antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SIK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.
  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 30 (EIEE30)
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Note=Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, AMPK subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11142

    OMIM: 605705

    KEGG: hsa:102724428

    STRING: 9606.ENSP00000270162

    UniGene: Hs.282113



主站蜘蛛池模板: 正在播放国产真实露脸高清| 一本大道东京热无码| 四虎永久在线精品免费网站| 国产无套中出学生姝| 国产精品兄妹在线观看麻豆| 国产偷人妻精品一区二区在线 | 韩国久久久久久级做爰片| 久久中文字幕乱码久久午夜 | 偷偷色噜狠狠狠狠的777米奇| 激情内射日本一区二区三区| 亚洲精品亚洲人成在线| 久久婷婷五月综合色和| 国产精品特黄aaaa片在线观看| 亚洲一二区制服无码中字 | 国产美女裸体无遮挡免费视频 | 欧美日韩在线视频一区| 无码专区人妻系列日韩精品少妇| 亚洲欧美日韩国产成人| 亚洲色大成网站在线| 欧美牲交视频免费观看| 亚洲国产中文在线视频| 免费精品99久久国产综合精品 | 中文字幕无码热在线视频| 久久国产人妻一区二区| 欧美怡红院免费全部视频| 成人性生交片无码免费看| 久久精品国产亚洲夜色av网站| 久久精品国产99久久久小说| 亚洲精品无码鲁网午夜| 无码国产精品久久一区免费| 亚洲乱码中文字幕在线| 国产情侣草莓视频在线| 一区二区三区四区在线不卡高清 | 亚洲精品成人区在线观看| 亚洲精品久久7777777| 忘忧草日本在线播放www| 69久久精品无码一区二区无码| 亚洲丁香五月天缴情综合| 国产日产欧产美| 一本大道在线观看无码一区| 人人爽人人澡人人人人妻|