在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SIK1 Antibody, FITC conjugated

  • 中文名稱:
    SIK1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA021321LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SIK1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SIK1
  • 別名:
    KID2 antibody; MSK antibody; myocardial SNF1 like kinase antibody; QIK antibody; Qin-induced kinase antibody; Salt inducible kinase 1 antibody; Salt-inducible protein kinase 1 antibody; Serine threonine protein kinase SNF1 like kinase 1 antibody; Serine threonine protein kinase SNF1LK antibody; Serine/threonine-protein kinase SIK1 antibody; Serine/threonine-protein kinase SNF1-like kinase 1 antibody; Serine/threonine-protein kinase SNF1LK antibody; SIK-1 antibody; SIK1 antibody; SIK1_HUMAN antibody; SNF1 like kinase antibody; Snf1lk antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase SIK1 protein (492-750AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.
  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 30 (EIEE30)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, AMPK subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11142

    OMIM: 605705

    KEGG: hsa:102724428

    STRING: 9606.ENSP00000270162

    UniGene: Hs.282113



主站蜘蛛池模板: 久久久久九九精品影院| 国产美女亚洲精品久久久| 亚洲最大无码av网站观看| 国产无套露脸在线观看| 色无码av在线播放| 色综亚洲国产vv在线观看| 中文天堂国产最新| 人妻av中文字幕久久| 午夜精品乱人伦小说区| 欧美丰满熟妇xx猛交| 麻豆精品国产精华精华液好用吗 | 国产欧美精品一区二区三区-老狼| 成年片色大黄全免费软件到| 天堂亚洲2017在线观看| 人妻少妇久久中文字幕| 国产午夜福利短视频| 国产色产综合色产在线视频| 无遮挡午夜男女xx00动态| 疯狂迎合进入强壮公的视频| 国产又爽又大又黄a片| 男ji大巴进入女人的视频| 亚洲精品午夜无码专区| 欧美黑人巨大videos精品男男| 99久久精品国产一区二区| 国产成人啪精品视频网站午夜 | 色播久久人人爽人人爽人人片av| 国产精品久久婷婷六月丁香| 免费无码观看的av在线播放| 久青草国产在视频在线观看| 欧美日本韩国亚洲| 国产福利视频一区二区| 免费人成在线观看视频无码| 无码免费中文字幕视频| 国产午夜成人久久无码一区二区| 日本无翼乌邪恶大全彩h| 黑人又粗又大又硬a片| 自拍偷自拍亚洲精品牛影院| 中文无码乱人伦中文视频在线v| 水蜜桃av无码| 国产精品国产三级国av| 免费无码又爽又刺激高潮的app |