在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SHC3 Antibody

  • 中文名稱:
    SHC3兔多克隆抗體
  • 貨號(hào):
    CSB-PA021256GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    N SHC antibody; N-Shc antibody; Neuronal Shc antibody; NSHC antibody; Protein Rai antibody; Rai antibody; SH2 domain protein C3 antibody; SHC (Src homology 2 domain containing) transforming protein 3 antibody; SHC adaptor protein 3 antibody; SHC protein C antibody; SHC-like protein, neuronal antibody; SHC-transforming protein 3 antibody; SHC-transforming protein C antibody; Shc3 antibody; Shc3 p51 antibody; SHC3_HUMAN antibody; SHCC antibody; Src homology 2 domain-containing transforming protein antibody; Src homology 2 domain-containing-transforming protein C3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SHC3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
  • 基因功能參考文獻(xiàn):
    1. High SHC3 expression is associated with glioblastoma. PMID: 25062668
    2. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
    3. Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
    4. amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. PMID: 19748727
    5. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. PMID: 11877420
    6. ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. PMID: 12185581
    7. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 12242309
    8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
    9. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. PMID: 15870690
    10. data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas PMID: 15940252
    11. 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. PMID: 17179996
    12. shcc is expressed in the human gut, especially in the enteric glial cells PMID: 17919311
    13. ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. PMID: 18997821

    顯示更多

    收起更多

  • 組織特異性:
    Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, me
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18181

    OMIM: 605263

    KEGG: hsa:53358

    STRING: 9606.ENSP00000364995

    UniGene: Hs.292737



主站蜘蛛池模板: 欧美日韩亚洲国产欧美电影 | 亚洲日韩av一区二区三区中文| 国产精品国产亚洲区艳妇糸列短篇| 中文字幕日韩人妻不卡一区| 国产一卡二卡三卡四卡视频版| 精品一区二区三区在线成人| 国产综合在线观看| 亚洲欧洲∨国产一区二区三区| 同性女女黄h片在线播放| 人妻无码精品久久亚瑟影视 | 天堂va欧美va亚洲va好看va| 日韩欧美国产aⅴ另类| 免费精品99久久国产综合精品| 国产蜜臀av在线一区尤物| 欧美高清精品一区二区| 亚洲春色av无码专区在线播放 | 亚洲熟妇自偷自拍另类| 国产精品永久免费视频| 秋霞av在线露丝片av无码| 日本一本一区二区免费播放| 日韩精品无码一区二区三区久久久 | 久久久精品人妻一区二区三区蜜桃| 人人妻人人澡人人爽超污| 亚洲理论在线a中文字幕| 一区二区三区国产精华液| 精品人人妻人人澡人人爽牛牛| 少妇被粗大的猛进69视频| 亚洲aⅴ在线无码播放毛片一线天| 2019久久久最新精品| 99久久免费国产精精品| 亚洲妇女无套内射精| 中文乱码字幕高清一区二区| 国产台湾无码av片在线观看| 国产大片黄在线观看| 老牛精品亚洲成av人片| 国产亚洲熟妇综合视频| 国产欧美va天堂在线观看视频下载| 久久久国产精品消防器材| 色欲久久综合亚洲精品蜜桃| 少妇高潮喷水惨叫久久久久电影 | 天天干天天日夜夜操|