在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SHC3 Antibody

  • 中文名稱:
    SHC3兔多克隆抗體
  • 貨號(hào):
    CSB-PA021256GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    N SHC antibody; N-Shc antibody; Neuronal Shc antibody; NSHC antibody; Protein Rai antibody; Rai antibody; SH2 domain protein C3 antibody; SHC (Src homology 2 domain containing) transforming protein 3 antibody; SHC adaptor protein 3 antibody; SHC protein C antibody; SHC-like protein, neuronal antibody; SHC-transforming protein 3 antibody; SHC-transforming protein C antibody; Shc3 antibody; Shc3 p51 antibody; SHC3_HUMAN antibody; SHCC antibody; Src homology 2 domain-containing transforming protein antibody; Src homology 2 domain-containing-transforming protein C3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SHC3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
  • 基因功能參考文獻(xiàn):
    1. High SHC3 expression is associated with glioblastoma. PMID: 25062668
    2. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
    3. Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
    4. amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. PMID: 19748727
    5. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. PMID: 11877420
    6. ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. PMID: 12185581
    7. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 12242309
    8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
    9. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. PMID: 15870690
    10. data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas PMID: 15940252
    11. 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. PMID: 17179996
    12. shcc is expressed in the human gut, especially in the enteric glial cells PMID: 17919311
    13. ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. PMID: 18997821

    顯示更多

    收起更多

  • 組織特異性:
    Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, me
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18181

    OMIM: 605263

    KEGG: hsa:53358

    STRING: 9606.ENSP00000364995

    UniGene: Hs.292737



主站蜘蛛池模板: 级r片内射在线视频播放| 国产在线一区二区av视频| 曰韩少妇内射免费播放| 男人a天堂手机在线版| 学生妹无套内射正在播放| 成人无码视频在线观看网址| 18禁超污无遮挡无码免费动态图 | 国产香蕉尹人在线观看视频| 精品午夜福利无人区乱码一区| 国产舌乚八伦偷品w中| 人妻少妇邻居少妇好多水在线| 国产精品亚洲玖玖玖在线观看| 人妻三级日本香港三级极97| 好吊色欧美一区二区三区四区| 噜妇插内射精品| 欧美日韩不卡视频合集| 精品日本一区二区免费视频| 日本日本乱码伦专区| 丰满少妇人妻无码专区| 精品一区二区三区免费播放| 中文乱码免费一区二区| 国产无套水多在线观看| 性暴力欧美猛交在线播放| 人人妻人人澡人人爽不卡视频 | 国产成年无码久久久久毛片| 精品高潮呻吟99av无码视频| 成人无码www在线看免费| 99热精品国自产拍天天拍| 国产在线不卡精品网站| 无码一区二区| 欧美激情精品久久久久久| 亚洲人成电影网站色迅雷| 久久成人伊人欧洲精品| 熟女视频一区二区在线观看 | 国产成人精品一区二区三区免费| 国产人妻精品一区二区三区| 香蕉欧美成人精品a∨在线观看 | 波多野结衣av在线无码中文18| 亚洲精品四区麻豆文化传媒| 国产在线观看无码免费视频| 国产午夜无码视频在线观看|