在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SERPINB1 Antibody

  • 中文名稱:
    SERPINB1兔多克隆抗體
  • 貨號:
    CSB-PA572039
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA572039(SERPINB1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SERPINB1
  • 別名:
    Anti elastase antibody; EI antibody; ELANH2 antibody; Epididymis luminal protein 57 antibody; HEL57 antibody; ILEU_HUMAN antibody; LEI antibody; Leukocyte elastase inhibitor antibody; M/NEI antibody; MNEI antibody; Monocyte/neutrophil elastase inhibitor antibody; Peptidase inhibitor 2 antibody; Pi-2 antibody; PI2 antibody; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1 antibody; Serpin B1 antibody; Serpin peptidase inhibitor clade B (ovalbumin) member 1 antibody; serpinb1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human SERPINB1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
  • 基因功能參考文獻:
    1. The expression of SERPINB1 was approximately 2-fold higher in apical periodontitis. SERPINB1 expression was noted in neutrophils and epithelial cells. PMID: 28673495
    2. SERPINB1 decreased inflammation, ameliorated oxidative stress in the lung, and attenuated acute lung injury in rats with orthotopic autologous liver transplantation by activating HO-1 and it does so through STAT3 PMID: 28427999
    3. a relatively low Serpinb1a protein threshold in neutrophils that is required for sustained survival PMID: 27107834
    4. SERPINB1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Data show that high serpin B1 protein (SERPINB1) gene expression was associated with favorable tumor response and prolonged survival under cisplatin-based chemotherapy. PMID: 26799424
    6. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. PMID: 26993499
    7. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors PMID: 26963506
    8. is not expressed in neutrophils of both sulfur mustard-exposed and chronic obstructive pulmonary disease patients PMID: 24852194
    9. Data suggest that serine protease inhibitor (SERPIN) B1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of matrix metalloproteinase-2 and the activation of focal adhesion kinase. PMID: 24968089
    10. Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. PMID: 24105272
    11. Apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. PMID: 23673989
    12. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. PMID: 23269243
    13. In the resting state during human neutrophil extracellar trap generation, SerpinB1 is exclusively in the cytoplasm, consistent with the current understanding of clade B serpins, and it may migrate and regulate events in the cell nucleus. PMID: 23002442
    14. These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease. PMID: 22421620
    15. serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses. PMID: 21248149
    16. The findings define an innate role for SerpinB1 in cystic fibrosis airways. PMID: 20817705
    17. M/NEI is a dual specificity inhibitor with two adjacent reactive sites that support rapid efficient inhibitory reactions with cellular proteases, including the three neutrophil granule proteases. PMID: 11747453

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Cytoplasm. Cytolytic granule. Early endosome.
  • 蛋白家族:
    Serpin family, Ov-serpin subfamily
  • 組織特異性:
    In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.
  • 數據庫鏈接:

    HGNC: 3311

    OMIM: 130135

    KEGG: hsa:1992

    STRING: 9606.ENSP00000370115

    UniGene: Hs.381167



主站蜘蛛池模板: 丝袜老师办公室里做好紧好爽| 夜夜高潮夜夜爽夜夜爱爱一区 | 天堂最新版资源网| 亚洲综合色区另类小说| 欧美三級片黃色三級片黃色| 成在线人免费视频播放| 久久综合婷婷丁香五月中文字幕| 男女性高爱潮免费网站| 国产成人av无码精品| 小sao货水好多真紧h无码视频 | 久久人人爽人人爽人人片av| 强开小婷嫩苞又嫩又紧韩国视频| 又爽又黄无遮挡高潮视频网站| 免费观看日本污污ww网站| 亚洲色无码中文字幕yy51999| 亚洲欧美丝袜精品久久| 18禁黄无遮挡网站免费| 亚洲国产成人久久久网站| 国产av天堂亚洲国产av麻豆| 国产做a爰片久久毛片a片| 精品人妻伦九区久久aaa片| 国产极品粉嫩馒头一线天av| 国产精品卡1卡2卡3网站| 国产乱码一区二区三区爽爽爽| 无码人妻一区二区三区在线| 豆国产96在线 | 亚洲| 2018亚洲а∨天堂| 亚洲国产码专区| 日本亚洲欧洲无免费码在线| 天天做天天爱天天综合网| 色噜噜亚洲男人的天堂| 日本一卡二卡3卡四卡网站精品| 中文精品久久久久国产网址| 欧美人与物videos另类xxxxx| 久久人妻国产精品| 免费无码又爽又刺激高潮的app | 国产老熟女狂叫对白| 可以直接免费观看的av网站| 国产农村乱对白刺激视频| 麻豆熟妇人妻xxxxxx| 亚洲一区二区av在线观看|