在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SERPINB1 Antibody

  • 中文名稱:
    SERPINB1兔多克隆抗體
  • 貨號(hào):
    CSB-PA021065ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Leukocyte elastase inhibitor antibody at 4μg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43, 27 kDa
      Observed band size: 43 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA021065ESR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SERPINB1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SERPINB1
  • 別名:
    Anti elastase antibody; EI antibody; ELANH2 antibody; Epididymis luminal protein 57 antibody; HEL57 antibody; ILEU_HUMAN antibody; LEI antibody; Leukocyte elastase inhibitor antibody; M/NEI antibody; MNEI antibody; Monocyte/neutrophil elastase inhibitor antibody; Peptidase inhibitor 2 antibody; Pi-2 antibody; PI2 antibody; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 1 antibody; Serpin B1 antibody; Serpin peptidase inhibitor clade B (ovalbumin) member 1 antibody; serpinb1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Leukocyte elastase inhibitor protein (100-379AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
  • 基因功能參考文獻(xiàn):
    1. The expression of SERPINB1 was approximately 2-fold higher in apical periodontitis. SERPINB1 expression was noted in neutrophils and epithelial cells. PMID: 28673495
    2. SERPINB1 decreased inflammation, ameliorated oxidative stress in the lung, and attenuated acute lung injury in rats with orthotopic autologous liver transplantation by activating HO-1 and it does so through STAT3 PMID: 28427999
    3. a relatively low Serpinb1a protein threshold in neutrophils that is required for sustained survival PMID: 27107834
    4. SERPINB1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Data show that high serpin B1 protein (SERPINB1) gene expression was associated with favorable tumor response and prolonged survival under cisplatin-based chemotherapy. PMID: 26799424
    6. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. PMID: 26993499
    7. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors PMID: 26963506
    8. is not expressed in neutrophils of both sulfur mustard-exposed and chronic obstructive pulmonary disease patients PMID: 24852194
    9. Data suggest that serine protease inhibitor (SERPIN) B1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of matrix metalloproteinase-2 and the activation of focal adhesion kinase. PMID: 24968089
    10. Decreased expression of SERPINB1 correlates with tumor invasion and poor prognosis in hepatocellular carcinoma. PMID: 24105272
    11. Apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. PMID: 23673989
    12. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. PMID: 23269243
    13. In the resting state during human neutrophil extracellar trap generation, SerpinB1 is exclusively in the cytoplasm, consistent with the current understanding of clade B serpins, and it may migrate and regulate events in the cell nucleus. PMID: 23002442
    14. These results suggest that serpin B1 may be a novel marker of active ulcerative colitis and may play an important role in the pathogenesis of inflammatory bowel disease. PMID: 22421620
    15. serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses. PMID: 21248149
    16. The findings define an innate role for SerpinB1 in cystic fibrosis airways. PMID: 20817705
    17. M/NEI is a dual specificity inhibitor with two adjacent reactive sites that support rapid efficient inhibitory reactions with cellular proteases, including the three neutrophil granule proteases. PMID: 11747453

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted. Cytoplasm. Cytolytic granule. Early endosome.
  • 蛋白家族:
    Serpin family, Ov-serpin subfamily
  • 組織特異性:
    In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3311

    OMIM: 130135

    KEGG: hsa:1992

    STRING: 9606.ENSP00000370115

    UniGene: Hs.381167



主站蜘蛛池模板: 亚洲中文字幕久久精品无码va| 午夜精品一区二区三区的区别| 欧美大荫蒂毛茸茸视频| 少妇真实被内射视频三四区| 亚洲熟妇无码av另类vr影视| 国产av影片麻豆精品传媒| 天天天天做夜夜夜做| 少妇被爽到高潮动态图 | 久久久精品免费| 内射老妇bbwx0c0ck| 色综合色综合久久综合频道88| 亚洲毛片无码不卡av在线播放| 尤物蜜芽国产成人精品区| 成人午夜特黄aaaaa片男男 | 精品无码国产av一区二区| 亚洲中文字幕乱码电影| 丁香五月开心婷婷激情综合| 日韩 高清 无码 人妻| 疯狂三人交性欧美| 国产日韩欧美| 亚洲va中文字幕无码久久| 亚洲国产成人最新精品| 免费的av网站手机版| 黑鬼大战白妞高潮喷白浆| 偷看少妇自慰xxxx| 欧美精品videossex另类日本| 四虎精品成人a在线观看| 国产乱人伦app精品久久 | 国产无套粉嫩白浆在线观看| 18禁肉肉无遮挡无码网站| 香港日本三级亚洲三级| 午夜无码一区二区三区在线| 蜜桃av麻豆av果冻传媒| 国产精品无码免费播放| 两个人日本www免费版| 18禁无遮挡羞羞啪啪免费网站| 欧美黑人巨大videos精品| 欧美激情性做爰免费视频| 国产亚洲产品影视在线产品| 欧美天天拍在线视频| 巨人精品福利官方导航|