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SENP8 Antibody

  • 中文名稱:
    SENP8兔多克隆抗體
  • 貨號:
    CSB-PA951733
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA951733(SENP8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA951733(SENP8 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE,Lysate: 40 μg,Lane 1-6: 293T cells, Hela cells, Lovo cells, Raji cells, HUEVC cells, Mouse spleen tissue,Primary antibody: CSB-PA951733(SENP8 Antibody) at dilution 1/600 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SENP8
  • 別名:
    cysteine 2 antibody; DEN 1 antibody; DEN1 antibody; Deneddylase 1 antibody; Deneddylase-1 antibody; FKSG8 antibody; HsT17512 antibody; NEDD 8 specific protease 1 antibody; NEDD8 specific protease cysteine 2 antibody; NEDD8-specific protease 1 antibody; NEDP 1 antibody; NEDP1 antibody; Protease antibody; Protease,聽cysteine聽2 antibody; PRSC2 antibody; SENP8 antibody; SENP8_HUMAN antibody; Sentrin / SUMO specific protease SENP 8 antibody; Sentrin-specific protease 8 antibody; Sentrin/SUMO-specific protease SENP8 antibody; SUMO sentrin specific protease family member 8 antibody; SUMO/sentrin peptidase family member; NEDD8 specific antibody; SUMO/sentrin specific peptidase family member 8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Full length fusion protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
  • 基因功能參考文獻:
    1. Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. PMID: 28475037
    2. In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8. PMID: 25655932
    3. Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene. PMID: 23001041
    4. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
    5. A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches. PMID: 23209320
    6. the specificity of NEDD8-specific peptidase SENP8 PMID: 22110750
    7. Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation. PMID: 19784069
    8. NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes PMID: 12730221
    9. results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein PMID: 12759363
    10. X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis PMID: 15567417

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  • 蛋白家族:
    Peptidase C48 family
  • 組織特異性:
    Broadly expressed, with highest levels in kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 22992

    OMIM: 608659

    KEGG: hsa:123228

    STRING: 9606.ENSP00000340505

    UniGene: Hs.513002



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