在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SENP8 Antibody

  • 中文名稱:
    SENP8兔多克隆抗體
  • 貨號:
    CSB-PA117139
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HuvEc cells, using SENP8 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using SENP8 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SENP8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SENP8
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Internal of Human SENP8.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
  • 基因功能參考文獻:
    1. Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. PMID: 28475037
    2. In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8. PMID: 25655932
    3. Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene. PMID: 23001041
    4. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells. PMID: 23408908
    5. A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches. PMID: 23209320
    6. the specificity of NEDD8-specific peptidase SENP8 PMID: 22110750
    7. Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation. PMID: 19784069
    8. NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes PMID: 12730221
    9. results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein PMID: 12759363
    10. X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis PMID: 15567417

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase C48 family
  • 組織特異性:
    Broadly expressed, with highest levels in kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 22992

    OMIM: 608659

    KEGG: hsa:123228

    STRING: 9606.ENSP00000340505

    UniGene: Hs.513002



主站蜘蛛池模板: 久久777国产线看观看精品| 最近中文字幕mv在线视频看 | 国产精品久久毛片| 日本va欧美va精品发布| 人妻换人妻仑乱| 中文字幕aav| 国产女人抽搐喷浆视频| 国产美女牲交视频| 亚洲欧美日韩国产成人| 成人电线在线播放无码| 精品综合久久久久久97| 亚洲一区二区三区四区五区六| 国产精品无码无需播放器| 色综合网天天综合色中文| 92午夜福利少妇系列| 亚洲精品无码久久| 欧美巨鞭大战丰满少妇| 动漫av一区二区在线观看| 在线观看片免费人成视频无码| 免费国精产品wnw2544| 五月天激情电影| 国产亚洲熟妇在线视频| 日本嫩交12一16xxx视频| 五月丁香啪啪| 成人精品一区日本无码网站| 久久人午夜亚洲精品无码区| 久久久久久久久888| 一 级做人爱全视频在线看| 国产又黄又爽又色的免费| 一边摸一边叫床一边爽av| 噜噜噜亚洲色成人网站∨| 天堂在线中文网www| 国产日产欧产精品精品app| 在线成人爽a毛片免费软件| 奇米影视第四色首页| 特级a做爰全过程片| h人成在线看免费视频| 理论片午午伦夜理片影院99| 国产乡下三级全黄三级bd| 国产午精品午夜福利757视频播放| 亚洲精品无码久久久|