在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCTR Antibody

SCTR Antibody

  • 中文名稱：
    SCTR兔多克隆抗體
  • 貨號：
    CSB-PA336738
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA336738(SCTR Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA336738(SCTR Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SCTR; Secretin receptor; SCT-R
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SCTR
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻：
    1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls PMID: 27115285
    2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. PMID: 26740626
    4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. PMID: 26397240
    5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. PMID: 22565418
    7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. PMID: 23168245
    8. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma PMID: 19904746
    9. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. PMID: 19886671
    10. promoter methylation plays a role in the regulation of SR gene expression. PMID: 14645499
    11. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. PMID: 15706223
    12. There is a marked reduction in SCTR binding in ductal neoplasia. PMID: 16192632
    13. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. PMID: 16819820
    14. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma. PMID: 16935383
    15. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. PMID: 17678920
    16. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas PMID: 17711922
    17. secretin receptors are new markers for bronchopulmonary carcinoid tumors PMID: 18223557
    18. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. PMID: 18401761
    19. These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. PMID: 18680717

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數據庫鏈接：

    HGNC: 10608

    OMIM: 182098

    KEGG: hsa:6344

    STRING: 9606.ENSP00000019103

    UniGene: Hs.42091



主站蜘蛛池模板： 欧美性受xxxx黑人xyx性爽| 欧美国产日韩亚洲中文| 成人午夜福利免费体验区| 人妻av无码中文专区久久| 欧美黑人大战白嫩在线| 蜜臀av夜夜澡人人爽人人| 18禁裸男晨勃露j毛免费观看| 国产精品一区二区久久精品| 亚洲性人人天天夜夜摸| 午夜福利不卡片在线机免费视频 | 国产亚洲色婷婷久久99精品| 国产精品美脚玉足脚交| 国产草莓视频无码a在线观看| 国产成人无码短视频| 深夜福利视频在线播放| 最近中文2019字幕第二页| 免费人成在线观看成人片| 最近中文字幕mv在线视频看 | 亚洲精品成人久久电影网 | av无码人妻无码男人的天堂 | 国产无套露脸在线观看| 午夜dj在线观看免费视频| 久久久国产精品消防器材| 成人无码a片一区二区三区免| 亚洲国产成人精品无码区蜜柚| 国产亚洲精品成人aa片新蒲金 | 亚洲一区二区三区含羞草| 国产精品自在线拍国产手机版| 国内精品久久久久久久影视| 久久青青草原精品国产app| 粗大猛烈进出高潮视频| 亚洲婷婷综合色高清在线| 久久99精品久久久久久齐齐| 亚洲 一区二区 在线| 文中字幕一区二区三区视频播放 | 曰韩少妇内射免费播放| 亚洲乱码日产精品bd| 亚洲伊人成综合网| 97久久香蕉国产线看观看| 国产女人高潮抽搐叫床视频| 亚洲熟女av综合网五月|