在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Secretin receptor (SCTR), partial

Recombinant Human Secretin receptor (SCTR), partial

  • 中文名稱：
    人SCTR重組蛋白
  • 貨號：
    CSB-YP020865HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SCTR重組蛋白
  • 貨號：
    CSB-EP020865HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SCTR重組蛋白
  • 貨號：
    CSB-EP020865HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SCTR重組蛋白
  • 貨號：
    CSB-BP020865HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SCTR重組蛋白
  • 貨號：
    CSB-MP020865HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SCTR; Secretin receptor; SCT-R
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻：
    1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls PMID: 27115285
    2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. PMID: 26740626
    4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. PMID: 26397240
    5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. PMID: 22565418
    7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. PMID: 23168245
    8. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma PMID: 19904746
    9. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. PMID: 19886671
    10. promoter methylation plays a role in the regulation of SR gene expression. PMID: 14645499
    11. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. PMID: 15706223
    12. There is a marked reduction in SCTR binding in ductal neoplasia. PMID: 16192632
    13. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. PMID: 16819820
    14. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma. PMID: 16935383
    15. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. PMID: 17678920
    16. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas PMID: 17711922
    17. secretin receptors are new markers for bronchopulmonary carcinoid tumors PMID: 18223557
    18. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. PMID: 18401761
    19. These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. PMID: 18680717

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數據庫鏈接：

    HGNC: 10608

    OMIM: 182098

    KEGG: hsa:6344

    STRING: 9606.ENSP00000019103

    UniGene: Hs.42091



主站蜘蛛池模板： 制服 丝袜 亚洲 中文 综合| 狠狠色丁香久久婷婷综合蜜芽五月 | 国语精品自产拍在线观看网站| 亚洲国产精品美女久久久久| 国产看黄网站又黄又爽又色| 九九综合九色综合网站| 国产在线高清理伦片a| 中国丰满熟妇av| 欧美亚洲日本高清不卡| 久久久久成人精品| 无码少妇a片一区二区三区| 永久免费男同av无码入口| 成人无遮挡裸免费视频在线观看| 天堂网www在线资源网| 国产成人精品a视频| 黄网站色视频免费国产| 国产精品aⅴ在线观看| 在线看片国产日韩欧美亚洲| 久久国产福利国产秒拍| 欧美丰满大乳大屁股流白浆| 青青青国产免a在线观看| 国产做爰又粗又大又爽动漫| 成人特级毛片www免费版| 午夜精品乱人伦小说区| 伦人伦xxx国产对白| 国产精品久久久久久亚洲影视| 精品午夜国产福利观看| 男女高潮喷水在线观看| 国产伦精品免编号公布| 玩弄人妻少妇500系列视频| 无码精品日韩专区| 免费毛儿一区二区十八岁| 欧美精品久久天天躁| 久久久www成人免费精品| 久久天堂av综合合色蜜桃网| 国产99视频精品免费视看6| 中文字幕无码精品亚洲35| 亚洲国产精彩中文乱码av| 人人澡人人澡人人看添av | 99精品国产兔费观看久久99| 久久久久 亚洲 无码 av 专区|