在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCTR Antibody, HRP conjugated

SCTR Antibody, HRP conjugated

  • 中文名稱：
    SCTR兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA020865LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SCTR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SCTR; Secretin receptor; SCT-R
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Secretin receptor protein (51-135AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻(xiàn)：
    1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls PMID: 27115285
    2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. PMID: 26740626
    4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. PMID: 26397240
    5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. PMID: 22565418
    7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. PMID: 23168245
    8. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma PMID: 19904746
    9. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. PMID: 19886671
    10. promoter methylation plays a role in the regulation of SR gene expression. PMID: 14645499
    11. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. PMID: 15706223
    12. There is a marked reduction in SCTR binding in ductal neoplasia. PMID: 16192632
    13. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. PMID: 16819820
    14. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma. PMID: 16935383
    15. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. PMID: 17678920
    16. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas PMID: 17711922
    17. secretin receptors are new markers for bronchopulmonary carcinoid tumors PMID: 18223557
    18. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. PMID: 18401761
    19. These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. PMID: 18680717

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10608

    OMIM: 182098

    KEGG: hsa:6344

    STRING: 9606.ENSP00000019103

    UniGene: Hs.42091



主站蜘蛛池模板： 天天做天天大爽天天爱| 中文字幕亚洲欧美日韩在线不卡 | 日日碰狠狠躁久久躁2023| 免费国产在线精品一区不卡| 中文人妻av大区中文不卡| 日韩欧美激情兽交| 国产freexxxx性播放麻豆| 中文久久乱码一区二区| 国产免费无码一区二区视频| 亚洲中文字幕永久在线全国| 午夜福利不卡片在线机免费视频| 日韩中文亚洲欧美视频二| 国产成人精品一区二区三区| 日日碰狠狠添天天爽| 人妻丰满熟妇av无码区不卡| 久久久久99精品成人片牛牛影视| 国产亚洲精品福利视频| 无码人妻精品一二三区免费| 国产午夜无码视频在线观看| 免费无码一区二区三区蜜桃大 | 国产午夜福利在线观看视频_| 久久久亚洲精品一区二区三区浴池| 欧美三级韩国三级日本三斤 | 2020久热爱精品视频在线观看| 国产无套精品一区二区三区| 成人做爰视频www网站小优视频| 又湿又黄裸乳漫画无遮挡网站| 国产亚洲精品视觉盛宴| 51久久国产露脸精品国产| 在线日韩日本国产亚洲| 欧美亚洲国产第一精品久久| 国产草草影院ccyycom| 国产 在线 | 日韩| 国产婷婷亚洲999精品小说 | 任我爽精品视频在线观看| 2022国产日产欧产精品| 精品国产乱码久久久久久鸭王1| 无码av最新无码av专区| 国产午夜不卡片免费视频| 久久久精品人妻无码专区不卡| av在线播放无码线|