在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCTR Antibody

SCTR Antibody

  • 中文名稱：
    SCTR兔多克隆抗體
  • 貨號：
    CSB-PA020865GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SCTR; Secretin receptor; SCT-R
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SCTR
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻：
    1. elevated in primary sclerosing cholangitis liver samples compared to healthy controls PMID: 27115285
    2. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    3. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains. PMID: 26740626
    4. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation. PMID: 26397240
    5. High SCTR expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    6. Results suggest that Secretin is a potent modulator of adipocyte functions, demonstrating overall a role in enhanced substrate cycling. PMID: 22565418
    7. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation. PMID: 23168245
    8. results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma PMID: 19904746
    9. Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor. PMID: 19886671
    10. promoter methylation plays a role in the regulation of SR gene expression. PMID: 14645499
    11. Secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer of human cerebellum. PMID: 15706223
    12. There is a marked reduction in SCTR binding in ductal neoplasia. PMID: 16192632
    13. Secretin receptor oligomerization occurs through -GxxxG- motif-independent interactions of transmembrane segments during the maturation of nascent molecules. PMID: 16819820
    14. The high receptor expression in cholangiocarcinomas may be used for in vivo secretin receptor-targeting of these tumors and for the differential diagnosis with hepatocellular carcinoma. PMID: 16935383
    15. A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation. PMID: 17678920
    16. Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas PMID: 17711922
    17. secretin receptors are new markers for bronchopulmonary carcinoid tumors PMID: 18223557
    18. Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other. PMID: 18401761
    19. These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers. PMID: 18680717

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數據庫鏈接：

    HGNC: 10608

    OMIM: 182098

    KEGG: hsa:6344

    STRING: 9606.ENSP00000019103

    UniGene: Hs.42091



主站蜘蛛池模板： 少妇又爽又刺激视频| 亚洲高清成人av电影网站| 色悠久久久久综合欧美99| 亚洲中文字幕码在线电影| 国产360激情盗摄全集| 69国产精品久久久久久人妻| 无码乱人伦一区二区亚洲| 亚洲中文字幕无码中字| 国产精品熟妇视频国产偷人| 最新国产精品自在线观看| 亚洲精品av一二三区无码| 亚洲国产成人久久精品99| 久久精品一区二区免费播放| 亚洲国产成人精品女人久久久 | 中国老熟女重囗味hdxx| 毛片无码国产| 久久精品国产99国产精品导航 | 国产一区二区三区四区精华| 国产又黄又湿无遮挡免费视频 | 国产品无码一区二区三区在线| 长腿校花无力呻吟娇喘| 欧美 国产 亚洲视频| av人摸人人人澡人人超碰手机版| 无码精品人妻一区二区三区湄公河 | 亚洲精品一卡2卡三卡4卡| 永久免费不卡在线观看黄网站| 色丁香婷婷综合久久| 亚洲精品国产福利一区二区| 男人吃奶摸下挵进去好爽| 欧美放荡的少妇| 午夜精品久久久久久久无码| 伊人久久综合成人网| 18禁男女污污污午夜网站免费暖暖| 又色又爽又黄的视频国内| 久久99精品国产麻豆宅宅| 玖玖资源站最稳定网址| 无码国产片观看| 被拉到野外强要好爽黑人| 人妻丰满熟妇aⅴ无码| 99久久精品无码一区二区毛片| 极品国产主播粉嫩在线|