在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SCIN Antibody

  • 中文名稱:
    SCIN兔多克隆抗體
  • 貨號:
    CSB-PA020823GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Adseverin antibody; ADSV_HUMAN antibody; KIAA1905 antibody; Scin antibody; Scinderin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SCIN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
  • 基因功能參考文獻:
    1. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH). PMID: 28213129
    2. Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion. PMID: 27347659
    3. High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia. PMID: 27033455
    4. Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process. PMID: 25174406
    5. SCIN plays an important role in lung carcinoma cell proliferation PMID: 25303873
    6. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer PMID: 24212916
    7. Scinderin expression does not correlate with prognosis in head and neck cancer. PMID: 24330498
    8. calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2 PMID: 19666531

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, podosome.
  • 蛋白家族:
    Villin/gelsolin family
  • 組織特異性:
    Expressed in megakaryocytes.
  • 數據庫鏈接:

    HGNC: 21695

    OMIM: 613416

    KEGG: hsa:85477

    STRING: 9606.ENSP00000297029

    UniGene: Hs.633359



主站蜘蛛池模板: 亚洲伊人久久大香线蕉| 国产成人无码18禁午夜福利p| 欧美精品乱码99久久蜜桃 | 亚洲精品欧美综合一区二区| 国产成人愉拍免费视频| 日本乱偷人妻中文字幕| 精品免费久久久久久久| 97视频精品全国免费观看| 曰韩a∨无码一区二区三区| 麻豆果冻传媒2021精品传媒一区| www国产精品内射老师| 亚洲 欧美 成人 自拍 高清| 国精品99久9在线 | 免费| 久久av高潮av无码av喷吹| 日本被黑人强伦姧人妻完整版| 高清粉嫩无套内谢国语播放| 国产成熟妇女性视频电影| 国产成人无码一区二区在线播放| 国产精品天干天干综合网| 97人妻无码一区| 亚洲熟妇av日韩熟妇av| 最新高清无码专区| 少妇与黑人一二三区无码| 日本国产成人国产在线播放| 午夜少妇性影院私人影院在线| 爱做久久久久久| 欧美不卡一卡二卡三卡| 日本国产一区二区三区在线观看| 97高清国语自产拍| 亚洲熟妇无码乱子av电影| 精品系列无码一区二区三区| 亚洲人成无码网www| 狠狠躁夜夜躁人人爽天天5| 99热门精品一区二区三区无码| 国产中的精品av一区二区| 亚洲人成网站在线观看69影院 | 国产精品青草久久久久福利99| 无码国产精品一区二区免费式影视| 人妻精品国产一区二区| 国产亚洲另类无码专区| 亚洲一区二区三区四区五区六|