在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCIN Antibody, FITC conjugated

SCIN Antibody, FITC conjugated

  • 中文名稱：
    SCIN兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA020823LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Adseverin antibody; ADSV_HUMAN antibody; KIAA1905 antibody; Scin antibody; Scinderin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Adseverin protein (556-703AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
  • 基因功能參考文獻：
    1. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH). PMID: 28213129
    2. Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion. PMID: 27347659
    3. High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia. PMID: 27033455
    4. Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process. PMID: 25174406
    5. SCIN plays an important role in lung carcinoma cell proliferation PMID: 25303873
    6. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer PMID: 24212916
    7. Scinderin expression does not correlate with prognosis in head and neck cancer. PMID: 24330498
    8. calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2 PMID: 19666531

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, podosome.
  • 蛋白家族：
    Villin/gelsolin family
  • 組織特異性：
    Expressed in megakaryocytes.
  • 數據庫鏈接：

    HGNC: 21695

    OMIM: 613416

    KEGG: hsa:85477

    STRING: 9606.ENSP00000297029

    UniGene: Hs.633359



主站蜘蛛池模板： 日本丰满妇人成熟免费中文字幕| 精品人妻系列无码人妻漫画| 国产极品美女高潮无套在线观看 | 国产网红无码精品视频| 精品久久久久久成人av| 亚洲日韩欧洲无码av夜夜摸| 国产sm精品调教视频网址 | 国产美女自慰在线观看| 久久综合久久鬼色| 亚洲高清专区日韩精品| 亚洲国产精品无码久久| 亚洲多毛妓女毛茸茸的| 日韩人妻无码精品免费shipin| 伊人久久丁香色婷婷啪啪| 日韩不卡1卡2卡三卡2021精品推荐 | av天堂久久精品影音先锋| 久久精品无码av| 国产精品99久久久精品无码| 午夜影视啪啪免费体验区入口| 成人免费网站视频www| 性一交一乱一乱一视频| 国产爆乳无码一区二区麻豆| 久久精品国产亚洲欧美成人 | 中国内射xxxx6981少妇| 国产女人乱子对白av片 | 欧美人成视频在线视频| 亚洲精品揄拍自拍首页一| 少妇无码av无码专区在线观看| www亚洲精品久久久| 青草草97久热精品视频| 粉色午夜视频| 无码人妻一区二区三区精品视频| 18禁美女黄网站色大片免费网站 | 无码中文字幕av免费放| 中文字幕无码日韩中文字幕| 亚洲欧洲日产国码无码av一| 国产精品无码综合区| 国产色诱视频在线播放网站| 亚洲色成人中文字幕网站 | 欧美高清在线精品一区| 99久久国产露脸精品国产麻豆|