在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCIN Antibody, Biotin conjugated

SCIN Antibody, Biotin conjugated

  • 中文名稱：
    SCIN兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA020823LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCIN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Adseverin antibody; ADSV_HUMAN antibody; KIAA1905 antibody; Scin antibody; Scinderin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Adseverin protein (556-703AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
  • 基因功能參考文獻：
    1. Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH). PMID: 28213129
    2. Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion. PMID: 27347659
    3. High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia. PMID: 27033455
    4. Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process. PMID: 25174406
    5. SCIN plays an important role in lung carcinoma cell proliferation PMID: 25303873
    6. These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer PMID: 24212916
    7. Scinderin expression does not correlate with prognosis in head and neck cancer. PMID: 24330498
    8. calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2 PMID: 19666531

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, podosome.
  • 蛋白家族：
    Villin/gelsolin family
  • 組織特異性：
    Expressed in megakaryocytes.
  • 數據庫鏈接：

    HGNC: 21695

    OMIM: 613416

    KEGG: hsa:85477

    STRING: 9606.ENSP00000297029

    UniGene: Hs.633359



主站蜘蛛池模板： 久久精品无码免费不卡| 女人爽到高潮免费看视频| 影音先锋无码aⅴ男人资源站| 久久精品国产99国产精品导航| 久久er热在这里只有精品66| 2020国产精品永久在线| 久热爱精品视频线路一| 亚洲精品乱码久久久久久按摩| 日本阿v网站在线观看中文| 国产网友自拍在线视频| 国产在线一卡2卡三卡4卡免费| 亚洲色在线无码国产精品| 99大香伊乱码一区二区| 精品成人av一区二区三区| 风流老熟女一区二区三区| 伊人久久大香线蕉午夜av| 久久亚洲色www成人男男| 国产精品亚洲二区在线看| 国产日产韩国精品视频| 国产精品久久久久久亚洲影视内衣 | 精品无人区一区二区三区| 又粗又猛又黄又爽无遮挡| 国产一卡二卡三新区2022| av天堂午夜精品一区| 国产高清av在线播放| 国产精品免费观看调教网| 怡红院一区二区三区在线| 性色做爰片在线观看ww| 人妻系列无码专区久久五月天| 2019亚洲午夜无码天堂| 在线播放国产精品三级| 久久国产精品99国产精| 永久免费的av片在线电影网| 国色天香精品一卡2卡3卡4| 国模杨依粉嫩蝴蝶150p| 蜜臀久久99精品久久久久久| 日韩在线一区二区三区免费视频| 成人做爰视频www网站| 狠狠色狠狠色综合网| 日韩综合无码一区二区| 日本道精品一区二区三区|