在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SAR1B Antibody

  • 中文名稱:
    SAR1B兔多克隆抗體
  • 貨號:
    CSB-PA296125
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody.
    • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SAR1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human SAR1B.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
  • 基因功能參考文獻:
    1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
    2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
    3. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse. PMID: 28982670
    4. SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening. PMID: 25703997
    5. Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL. PMID: 25826777
    6. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
    7. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
    8. Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c. PMID: 21836065
    9. Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. PMID: 19846172
    10. identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption PMID: 12692552
    11. Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation. PMID: 15943909
    12. Five mutations in the SAR1B gene causing Anderson disease. PMID: 17945526
    13. muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues PMID: 18786134

    顯示更多

    收起更多

  • 相關疾病:
    Chylomicron retention disease (CMRD)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
  • 蛋白家族:
    Small GTPase superfamily, SAR1 family
  • 組織特異性:
    Expressed in many tissues including small intestine, liver, muscle and brain.
  • 數據庫鏈接:

    HGNC: 10535

    OMIM: 246700

    KEGG: hsa:51128

    STRING: 9606.ENSP00000385432

    UniGene: Hs.432984



主站蜘蛛池模板: 国产精品青青青在线观看| 欧美熟妇另类久久久久久多毛 | 无码av专区丝袜专区| 久久国产成人精品av| 337p日本欧洲亚洲大胆| 免费无遮挡无码视频网站| 337p粉嫩日本欧洲亚福利| 免费大片av手机看片不卡| 国产在线观看无码免费视频| ass日本丰满熟妇pics| 凹凸精品熟女在线观看| 成人亚洲精品久久99狠狠| 性无码专区一色吊丝中文字幕| 国产欧美一区二区三区在线看| 艳妇臀荡乳欲伦69调教视频| 欧美xxxx做受欧美1314| 精品无码一区在线观看| 四虎永久在线精品免费一区二区| 精品无码一区二区三区| 亚洲精品av中文字幕在线| 国产九九99久久99大香伊| 日韩av高潮喷水在线观看| 亚洲a无码综合a国产av中文 | 国产成人一区二区三区app| 国产免费看插插插视频| 国产精品欧美福利久久| 四虎影视884a精品国产| 国产高清乱理伦片中文小说| 男女做爰猛烈叫床视频免费| 丰满少妇人妻久久久久久| 国产 校园 另类 小说区| 野花社区www视频最新资源| 国产免费又色又爽粗视频| 国产动作大片中文字幕| 97在线成人国产在线视频| 亚洲自偷自拍另类12p| 国产在线精品二区| 国产精品久免费的黄网站| 四虎成人永久在线精品免费| 国产免费一区二区三区不卡| 欧洲人妻丰满av无码久久不卡|