在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SAR1B Antibody

  • 中文名稱:
    SAR1B兔多克隆抗體
  • 貨號:
    CSB-PA296125
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from LOVO cells and RAW264.7 cells, using SAR1B antibody.
    • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using SAR1B antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SAR1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human SAR1B.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTP-binding protein involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Synergizes with the cargo receptor SURF4 to mediate the export of lipoproteins from the endoplasmic reticulum, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
  • 基因功能參考文獻:
    1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
    2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease PMID: 29540175
    3. Report compensatory Sar1a elevation after Sar1b gene deletion in Caco-2/15 cells prevents chylomicron collapse. PMID: 28982670
    4. SAR1B polymorphisms were associated with Alzheimer's disease (AD) risk; results were not significant after correction for multiple tests. Simultaneous screening using SAR1B rs11948613 and ApoE epsilon4 status offered a better sensitivity for AD screening. PMID: 25703997
    5. Our data also suggest that Sar1B overexpression contributes to regulation of CHOL transport and metabolism by facilitating rapid uptake and transport of CHOL. PMID: 25826777
    6. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
    7. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
    8. Sar1b expression may promote intestinal lipid transport with the involvement of the coat protein complex II network and the processing of SREBP-1c. PMID: 21836065
    9. Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene. PMID: 19846172
    10. identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption PMID: 12692552
    11. Sara2 is an important gene in processes involving erythroid cell proliferation and differentiation. PMID: 15943909
    12. Five mutations in the SAR1B gene causing Anderson disease. PMID: 17945526
    13. muscular as well as cardiac abnormalities that could be related to the reported expression of SARA2 in these tissues PMID: 18786134

    顯示更多

    收起更多

  • 相關疾病:
    Chylomicron retention disease (CMRD)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
  • 蛋白家族:
    Small GTPase superfamily, SAR1 family
  • 組織特異性:
    Expressed in many tissues including small intestine, liver, muscle and brain.
  • 數據庫鏈接:

    HGNC: 10535

    OMIM: 246700

    KEGG: hsa:51128

    STRING: 9606.ENSP00000385432

    UniGene: Hs.432984



主站蜘蛛池模板: 久久久久久久精品成人热色戒汤唯| 美女黄频视频大全免费的国内| 国产成+人+综合+亚洲欧美| 国产无遮挡又黄又爽网站| 少妇性l交大片欧洲热妇乱xxx| 国产精品乱码一区二区三| 新普新京亚洲欧美日韩国产| 欧美阿v高清资源在线| 国内精品人妻无码久久久影院蜜桃| 日韩av无码一区二区三区| 精产国品一二三产区9977| 国产亚洲精品久久一区二区| 中文成人无字幕乱码精品区| 人妻少妇偷人精品无码| 国产sm鞭打折磨调教视频 | 无码大潮喷水在线观看| 欧美牲交40_50a欧美牲交aⅴ| 好男人社区www在线官网| 久久精品成人欧美大片| av在线无码专区一区| 免费ā片在线观看| 高潮喷吹一区二区在线观看| 国产成av人片久青草影院| 国产人妖乱国产精品人妖| 免费观看18禁无遮挡真人网站| 十八禁啪啪无遮挡网站| 国产色秀视频在线播放| 国产v亚洲v天堂a无码| 国产亚洲精品久久久久小| 欧美丰满大爆乳波霸奶水多| 天天综合网天天综合色| 人人爽人人澡人人高潮| 大香伊蕉在人线国产网站首页| 亚洲va中文在线播放| 国产狂喷潮在线观看| 豆国产96在线 | 亚洲| 日本亚洲vr欧美不卡高清专区| 日本免费一区二区三区四区五区| 久久国产成人午夜av影院| 天天天天做夜夜夜夜做无码| 日本日本熟妇中文在线视频|