在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPS6KA6 Antibody

  • 中文名稱:
    RPS6KA6兔多克隆抗體
  • 貨號:
    CSB-PA077840
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA077840(RPS6KA6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA077840(RPS6KA6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    90 kDa ribosomal protein S6 kinase 6 antibody; KS6A6_HUMAN antibody; p90 RSK 6 antibody; p90-RSK 6 antibody; p90RSK6 antibody; pp90RSK4 antibody; Ribosomal protein S6 kinase 90kDa polypeptide 6 antibody; Ribosomal protein S6 kinase alpha 6 antibody; Ribosomal protein S6 kinase alpha-6 antibody; Ribosomal S6 kinase 4 antibody; rps6ka6 antibody; RSK 4 antibody; RSK-4 antibody; S6K-alpha-6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human RPS6KA6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
  • 基因功能參考文獻:
    1. RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma. PMID: 30143490
    2. The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signalregulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. PMID: 28731146
    3. RSK4 is expressed at low levels in malignant ovarian tumors, which correlates with advanced stages of the disease. PMID: 26732474
    4. downregulation of RSK4 expression is indicated to be associated with tumor cell proliferation and invasion, and silencing of the RSK4 may be involved in the development and progression of breast cancer PMID: 26397146
    5. Low RSK4 expression is correlated with advanced clinical pathologic classifications and is a poor overall survival in colorectal cancer patients PMID: 25197367
    6. RSK4 mRNA is significantly decreased in most of breast cancer tissues compared with paired non-cancerous tissues, due to promoter hypermethylation; frequent epigenetic inactivation might have a role in precancerous lesions or early cancer PMID: 24338215
    7. evaluated expression of RSK4 in renal cell carcinoma(RCC)tissues, analysed relationship between RSK4 expression and clinicopathological features of RCC patients and explored potential molecular mechanisms of RSK4 in RCC cell lines; expression pattern and molecular mechanisms of RSK4 in RCCs indicate it could be a potential independent prognostic factor PMID: 23942078
    8. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
    9. findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors PMID: 22020623
    10. Suggest that RSK4 may serve as a mediator of endothelial progenitor cell senescence in diabetes mellitus. PMID: 22297070
    11. The expression level of RSK-4 mRNA in breast cancer was significantly lower than those in normal breast tissues and breast benign lesions tissues. The down-regulation of RSK-4 expression in breast caner suggests that it is a breast cancer suppressor gene. PMID: 21875487
    12. Data indicate that RSK4 appears to be epigenetically silenced in endometrial cancer as evidenced by hypermethylation. PMID: 21372219
    13. importance of RSK4 for regulating senescence and indicate that downregulation of this kinase could be an important element in facilitating cell transformation. PMID: 21239520
    14. The unusual regulation and growth factor-independent activity of ribosomal S6 kinase 4 (RSK4) indicate that it is functionally distinct from other RSKs and may explain why RSK4 can participate in non-growth factor signaling. PMID: 15632195
    15. Downregulation of RPS6KA6 is associated with colon carcinoma. PMID: 16865262
    16. RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues. PMID: 17314274
    17. RSK4 expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells. PMID: 18628456
    18. Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas. PMID: 19584160

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 數據庫鏈接:

    HGNC: 10435

    OMIM: 300303

    KEGG: hsa:27330

    STRING: 9606.ENSP00000262752

    UniGene: Hs.234478



主站蜘蛛池模板: 日韩精品av一区二区三区| 激情欧美成人久久综合| 少妇无码av无码专区在线观看| 人妻熟人中文字幕一区二区| 日韩人妻无码免费视频一二区| 一区二三区在线 | 中国| 亚洲成av人影院| 真人做人试看60分钟免费| 亚洲熟妇av午夜无码不卡| 亚洲s久久久久一区二区| 日韩人妻一区二区三区蜜桃视频| 亚洲欧美综合区丁香五月小说| 黄网站成人片免费视频| 久久www色情成人免费观看| 欧美人与动牲交a精品| 亚洲人成人无码网www国产| 色偷偷亚洲精品一区二区| 精品乱码一区二区三四五区| 自拍性旺盛老熟女| 国内偷自第一区二区三区| 秋霞午夜鲁丝片午夜精品| 国精产品一区一区三区| 精品人妻码一区二区三区| 一本久久a久久免费精品不卡| 成人性无码专区免费视频| 日本熟妇人妻xxxx| 无码人妻一区二区三区免费视频| 日韩69永久免费视频| 少妇被粗大猛进进出出| 亚洲a∨无码一区二区| 亚洲欧美国产双大乳头| 国内精品伊人久久久久av影院| 97精品国产一区二区三区| 国产日产欧产精品| 18禁止午夜福利体验区| 亚洲精品nv久久久久久久久久 | 丰满人妻妇伦又伦精品国产| 精品亚洲国产成人a片app| 亚洲日本乱码一区二区产线一∨| 国产精品 视频一区 二区三区| 亚洲乱码无码永久不卡在线|