在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPS6KA6 Antibody

  • 中文名稱:
    RPS6KA6兔多克隆抗體
  • 貨號:
    CSB-PA044834
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from K562 cells and HT-29 cells, using S6K-α6 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using S6K-α6 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPS6KA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human S6K-α6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
  • 基因功能參考文獻:
    1. RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma. PMID: 30143490
    2. The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signalregulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. PMID: 28731146
    3. RSK4 is expressed at low levels in malignant ovarian tumors, which correlates with advanced stages of the disease. PMID: 26732474
    4. downregulation of RSK4 expression is indicated to be associated with tumor cell proliferation and invasion, and silencing of the RSK4 may be involved in the development and progression of breast cancer PMID: 26397146
    5. Low RSK4 expression is correlated with advanced clinical pathologic classifications and is a poor overall survival in colorectal cancer patients PMID: 25197367
    6. RSK4 mRNA is significantly decreased in most of breast cancer tissues compared with paired non-cancerous tissues, due to promoter hypermethylation; frequent epigenetic inactivation might have a role in precancerous lesions or early cancer PMID: 24338215
    7. evaluated expression of RSK4 in renal cell carcinoma(RCC)tissues, analysed relationship between RSK4 expression and clinicopathological features of RCC patients and explored potential molecular mechanisms of RSK4 in RCC cell lines; expression pattern and molecular mechanisms of RSK4 in RCCs indicate it could be a potential independent prognostic factor PMID: 23942078
    8. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
    9. findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors PMID: 22020623
    10. Suggest that RSK4 may serve as a mediator of endothelial progenitor cell senescence in diabetes mellitus. PMID: 22297070
    11. The expression level of RSK-4 mRNA in breast cancer was significantly lower than those in normal breast tissues and breast benign lesions tissues. The down-regulation of RSK-4 expression in breast caner suggests that it is a breast cancer suppressor gene. PMID: 21875487
    12. Data indicate that RSK4 appears to be epigenetically silenced in endometrial cancer as evidenced by hypermethylation. PMID: 21372219
    13. importance of RSK4 for regulating senescence and indicate that downregulation of this kinase could be an important element in facilitating cell transformation. PMID: 21239520
    14. The unusual regulation and growth factor-independent activity of ribosomal S6 kinase 4 (RSK4) indicate that it is functionally distinct from other RSKs and may explain why RSK4 can participate in non-growth factor signaling. PMID: 15632195
    15. Downregulation of RPS6KA6 is associated with colon carcinoma. PMID: 16865262
    16. RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues. PMID: 17314274
    17. RSK4 expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells. PMID: 18628456
    18. Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas. PMID: 19584160

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 數據庫鏈接:

    HGNC: 10435

    OMIM: 300303

    KEGG: hsa:27330

    STRING: 9606.ENSP00000262752

    UniGene: Hs.234478



主站蜘蛛池模板: 亚洲精品色播一区二区| 久久人人玩人妻潮喷内射人人| 97人人模人人爽人人少妇| 午夜精品久久久久久久久久久久| 欧美黑人又粗又硬xxxxx喷水| 亚洲中文有码字幕青青| 自拍偷自拍亚洲精品第1页| 国产又色又爽又刺激在线播放| 久久99精品久久久久久秒播| 亚洲国产精品日韩av不卡在线| 裸体女人高潮毛片| 亚洲国产另类久久久精品| 久久久国产一区二区三区四区小说| 国精产品999一区二区三区有限 | 中文字幕精品视频在线看免费 | 久久国产精品久久久久久| 狠狠色噜噜狠狠狠8888米奇| 亚洲精品久久久一二三区| 国产精品99久久免费观看| 无码人妻一区二区三区av | 国产亚洲精品久久一区二区| 人妻夜夜添夜夜无码av | 香蕉精品亚洲二区在线观看| 色偷偷偷久久伊人大杳蕉| 欧美真人性做爰全过程| 少妇把腿扒开让我爽爽视频| 亚洲国产欧美国产综合久久| 亚洲精品一卡2卡三卡4卡| 无码av一区二区三区无码| 天堂а√中文最新版地址在线| 性av盈盈无码天堂| 性色av无码久久一区二区三区| 99re6在线视频精品免费| 日韩人妻无码一区二区三区综合| 欧美特大特白屁股ass| 国产麻豆成人传媒免费观看| 国产精品无码a∨精品影院app| 亚州性无码不卡免费视频 | 高清一区二区三区免费视频| 国产av一区最新精品| 中文字幕人妻a片免费看|