在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RPS6KA6 Antibody, FITC conjugated

  • 中文名稱:
    RPS6KA6兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA891943LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RPS6KA6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    90 kDa ribosomal protein S6 kinase 6 antibody; KS6A6_HUMAN antibody; p90 RSK 6 antibody; p90-RSK 6 antibody; p90RSK6 antibody; pp90RSK4 antibody; Ribosomal protein S6 kinase 90kDa polypeptide 6 antibody; Ribosomal protein S6 kinase alpha 6 antibody; Ribosomal protein S6 kinase alpha-6 antibody; Ribosomal S6 kinase 4 antibody; rps6ka6 antibody; RSK 4 antibody; RSK-4 antibody; S6K-alpha-6 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ribosomal protein S6 kinase alpha-6 protein (340-467AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
  • 基因功能參考文獻:
    1. RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma. PMID: 30143490
    2. The regulatory role of RSK4 in breast cancer development was mediated by AKT and extracellular signalregulated kinase (ERK) signaling pathways and the expression of RSK4 was altered by DNA methylation in promoter regions. PMID: 28731146
    3. RSK4 is expressed at low levels in malignant ovarian tumors, which correlates with advanced stages of the disease. PMID: 26732474
    4. downregulation of RSK4 expression is indicated to be associated with tumor cell proliferation and invasion, and silencing of the RSK4 may be involved in the development and progression of breast cancer PMID: 26397146
    5. Low RSK4 expression is correlated with advanced clinical pathologic classifications and is a poor overall survival in colorectal cancer patients PMID: 25197367
    6. RSK4 mRNA is significantly decreased in most of breast cancer tissues compared with paired non-cancerous tissues, due to promoter hypermethylation; frequent epigenetic inactivation might have a role in precancerous lesions or early cancer PMID: 24338215
    7. evaluated expression of RSK4 in renal cell carcinoma(RCC)tissues, analysed relationship between RSK4 expression and clinicopathological features of RCC patients and explored potential molecular mechanisms of RSK4 in RCC cell lines; expression pattern and molecular mechanisms of RSK4 in RCCs indicate it could be a potential independent prognostic factor PMID: 23942078
    8. Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID: 23635776
    9. findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors PMID: 22020623
    10. Suggest that RSK4 may serve as a mediator of endothelial progenitor cell senescence in diabetes mellitus. PMID: 22297070
    11. The expression level of RSK-4 mRNA in breast cancer was significantly lower than those in normal breast tissues and breast benign lesions tissues. The down-regulation of RSK-4 expression in breast caner suggests that it is a breast cancer suppressor gene. PMID: 21875487
    12. Data indicate that RSK4 appears to be epigenetically silenced in endometrial cancer as evidenced by hypermethylation. PMID: 21372219
    13. importance of RSK4 for regulating senescence and indicate that downregulation of this kinase could be an important element in facilitating cell transformation. PMID: 21239520
    14. The unusual regulation and growth factor-independent activity of ribosomal S6 kinase 4 (RSK4) indicate that it is functionally distinct from other RSKs and may explain why RSK4 can participate in non-growth factor signaling. PMID: 15632195
    15. Downregulation of RPS6KA6 is associated with colon carcinoma. PMID: 16865262
    16. RT-PCR data show high expression of putative tumor suppressor genes Rsk4 and RbAp46 in 47% and 79% of breast carcinoma cases, respectively, whereas Cldn2 was down-regulated in 52% of breast cancer cases compared with normal adjacent tissues. PMID: 17314274
    17. RSK4 expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells. PMID: 18628456
    18. Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas. PMID: 19584160

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus. Note=Predominantly cytosolic.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 數據庫鏈接:

    HGNC: 10435

    OMIM: 300303

    KEGG: hsa:27330

    STRING: 9606.ENSP00000262752

    UniGene: Hs.234478



主站蜘蛛池模板: 中文字幕日韩精品亚洲一区| 无码人妻av一区二区三区蜜臀| 久久亚洲a片com人成| 亚洲欧美中文日韩v日本| 印度妓女野外xxww| 中文字幕亚洲码在线观看| 国产日韩在线时看高清视频| 亚洲熟女综合一区二区三区| 亚洲国产成人久久一区二区三区| 丁香五月婷激情综合第九色| 中本亚洲欧美国产日韩| 51国产偷自视频区视频| 一本色道久久88综合日韩精品| 久久激情日本亚洲欧洲国产中文| 国产成人夜色高潮福利影视| 92国产精品午夜福利免费| 成 人免费va视频| 免费国产va在线观看| 成人啪精品视频网站午夜| 午夜无码人妻av大片色欲| 波多野结衣av手机在线观看 | 亚洲欧洲综合有码无码| 日本乱偷人妻中文字幕| 国产成人小视频| 国产日产欧产美韩系列麻豆| 边喂奶边中出的人妻| 无码中文字幕日韩专区视频 | 国产一区二区三区 韩国女主播 | 欧美s码亚洲码精品m码| 国语精品福利自产拍在线观看| 亚洲亚洲人成综合丝袜图片| 无码超乳爆乳中文字幕| 伊人久久大香线蕉av一区| 爽爽午夜影视窝窝看片| 亚洲精品国产av成拍色拍婷婷| 非洲黑人最猛性xxxx交| 中无码人妻丰满熟妇啪啪| 日本一本一区二区免费播放| 久久午夜无码鲁丝片午夜精品| 色喜国模李晴超大尺度| 欧美日韩视频在线第一区|