在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ROBO3 Antibody

  • 中文名稱:
    ROBO3兔多克隆抗體
  • 貨號:
    CSB-PA846671ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA846671ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ROBO3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ROBO3
  • 別名:
    FLJ21044 antibody; HGPPS antibody; HGPS antibody; RB inhibiting gene 1 antibody; Rbig 1 antibody; Rbig1 antibody; Retinoblastoma inhibiting gene 1 antibody; Rig 1 antibody; Rig1 antibody; Robo 3 antibody; Robo3 antibody; Robo3 protein antibody; ROBO3_HUMAN antibody; Roundabout axon guidance receptor homolog 3 antibody; Roundabout homolog 3 antibody; Roundabout like protein 3 antibody; Roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody; Roundabout-like protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Roundabout homolog 3 protein (1237-1386AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
  • 基因功能參考文獻:
    1. In our case, we found a novel homozygous mutation p.R842* (c.2524C>T) causing a premature stop codon which is a disease-making mutation. PMID: 27267957
    2. confirmed that ROBO3 increases with clinical grade and miR-383 expression is inversely correlated to that of ROBO3 PMID: 26070964
    3. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330 PMID: 25882844
    4. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations). PMID: 24969490
    5. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1/2 into a late endosome- and lysosome-dependent degradation pathway. PMID: 24936616
    6. The novel ROBO3 mutation in this family may be among the most deleterious PMID: 21592015
    7. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations PMID: 21510772
    8. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis. PMID: 21850172
    9. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    10. identified mutations in the ROBO3 gene in patients affected with horizontal gaze palsy with progressive scoliosis (HGPPS);ROBO3 is required for hindbrain axon midline crossing PMID: 15105459
    11. The major clinical characteristics of patients with mutated ROBO3 were horizontal gaze palsy, progressive scoliosis, and brainstem malformations. PMID: 15824346
    12. Here we describe and compare two human Robo3 isoforms, Robo3A and Robo3B, which differ by the insertion of 26 amino acids at the N-terminus, and these forms appear to be evolutionary conserved PMID: 16226035
    13. Incidence of scoliosis in individuals harbouring heterozygous ROBO3 mutations may be greater than in the general population. PMID: 16525029
    14. No evidence for association between Gilles de la Tourette Syndrome and either the ROBO3 gene. Thus, this gene is unlikely to be the susceptibility genes contributing to GTS on 11q24. PMID: 17671968
    15. Four SNPs of ROBO3 showed associations with autism PMID: 18270976
    16. This study found five novel homozygous ROBO3 mutations (four missense mutations and one base deletion) distributed throughout the extracellular domain of the gene in consanguineous families with horizontal gaze palsy and progressive scoliosis. PMID: 18829051
    17. This is the second reported patient with synergistic convergence and the first associated with a documented pathologic genotype. PMID: 19041479
    18. mutations in the ROBO3 gene, which shares homology with roundabout genes important in axon guidance in developing Drosophila, zebrafish, and mouse. PMID: 15105459

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Gaze palsy, familial horizontal, with progressive scoliosis, 1 (HGPPS1)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, ROBO family
  • 數據庫鏈接:

    HGNC: 13433

    OMIM: 607313

    KEGG: hsa:64221

    STRING: 9606.ENSP00000380903

    UniGene: Hs.435621



主站蜘蛛池模板: 四虎国产精品永久入口| 亚洲中文久久精品无码1 | 精品一区二区国产在线观看 | 国产亚洲精品久久久网站好莱| 少妇高潮流白浆在线观看| 一本到中文无码av在线精品| 丰满少妇被猛烈进av毛片| 女人被黑人狂躁c到高潮小说| 一本大道久久东京热无码av| 精品久久久久久国产潘金莲| 亚洲综合久久成人a片| 丰满人妻被黑人猛烈进入| 高潮又爽又无遮挡又免费| 日日摸日日碰夜夜爽免费| 国产成人一区二区三区免费| 男女性色大片免费网站| 国产精品久久婷婷六月丁香 | 欧美激欧美啪啪片免费看| 娜娜麻豆国产电影| 性欧美老妇另类xxxx| 特级毛片爽www免费版| 国产熟妇疯狂4p交在线播放| 久久国产免费观看精品a片| 久久久久久久99精品免费观看 | 18禁无遮挡无码网站免费| 久久高清超碰av热热久久| 国产啪精品视频网站| 久久欧美国产伦子伦精品| 在线观看潮喷失禁大喷水无码| 在线精品无码字幕无码av| 美女裸体无遮挡免费视频网站| 国产高清午夜人成在线观看| 久久久婷婷五月亚洲97色| 蜜桃臀无码内射一区二区三区| 色情久久久av熟女人妻网站| 欧美一性一乱一交一免费视频| 秋霞av鲁丝片一区二区| 亚洲人成色4444在线观看| 日日摸日日碰夜夜爽免费| 久久97精品久久久久久久不卡| 亚洲人成色7777在线观看 |