在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ROBO3 Antibody

  • 中文名稱:
    ROBO3兔多克隆抗體
  • 貨號:
    CSB-PA291923
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA291923(ROBO3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA291923(ROBO3 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ROBO3
  • 別名:
    FLJ21044 antibody; HGPPS antibody; HGPS antibody; RB inhibiting gene 1 antibody; Rbig 1 antibody; Rbig1 antibody; Retinoblastoma inhibiting gene 1 antibody; Rig 1 antibody; Rig1 antibody; Robo 3 antibody; Robo3 antibody; Robo3 protein antibody; ROBO3_HUMAN antibody; Roundabout axon guidance receptor homolog 3 antibody; Roundabout homolog 3 antibody; Roundabout like protein 3 antibody; Roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody; Roundabout-like protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human ROBO3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
  • 基因功能參考文獻:
    1. In our case, we found a novel homozygous mutation p.R842* (c.2524C>T) causing a premature stop codon which is a disease-making mutation. PMID: 27267957
    2. confirmed that ROBO3 increases with clinical grade and miR-383 expression is inversely correlated to that of ROBO3 PMID: 26070964
    3. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330 PMID: 25882844
    4. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations). PMID: 24969490
    5. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1/2 into a late endosome- and lysosome-dependent degradation pathway. PMID: 24936616
    6. The novel ROBO3 mutation in this family may be among the most deleterious PMID: 21592015
    7. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations PMID: 21510772
    8. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis. PMID: 21850172
    9. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    10. identified mutations in the ROBO3 gene in patients affected with horizontal gaze palsy with progressive scoliosis (HGPPS);ROBO3 is required for hindbrain axon midline crossing PMID: 15105459
    11. The major clinical characteristics of patients with mutated ROBO3 were horizontal gaze palsy, progressive scoliosis, and brainstem malformations. PMID: 15824346
    12. Here we describe and compare two human Robo3 isoforms, Robo3A and Robo3B, which differ by the insertion of 26 amino acids at the N-terminus, and these forms appear to be evolutionary conserved PMID: 16226035
    13. Incidence of scoliosis in individuals harbouring heterozygous ROBO3 mutations may be greater than in the general population. PMID: 16525029
    14. No evidence for association between Gilles de la Tourette Syndrome and either the ROBO3 gene. Thus, this gene is unlikely to be the susceptibility genes contributing to GTS on 11q24. PMID: 17671968
    15. Four SNPs of ROBO3 showed associations with autism PMID: 18270976
    16. This study found five novel homozygous ROBO3 mutations (four missense mutations and one base deletion) distributed throughout the extracellular domain of the gene in consanguineous families with horizontal gaze palsy and progressive scoliosis. PMID: 18829051
    17. This is the second reported patient with synergistic convergence and the first associated with a documented pathologic genotype. PMID: 19041479
    18. mutations in the ROBO3 gene, which shares homology with roundabout genes important in axon guidance in developing Drosophila, zebrafish, and mouse. PMID: 15105459

    顯示更多

    收起更多

  • 相關疾病:
    Gaze palsy, familial horizontal, with progressive scoliosis, 1 (HGPPS1)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, ROBO family
  • 數據庫鏈接:

    HGNC: 13433

    OMIM: 607313

    KEGG: hsa:64221

    STRING: 9606.ENSP00000380903

    UniGene: Hs.435621



主站蜘蛛池模板: 国产亚洲999精品aa片在线爽| 无码日本精品xxxxxxxxx| 777奇米四色成人影视色区| 大屁股国产白浆一二区| 人妻熟女一区二区三区app下载 | 日韩精品中文字幕无码专区| 久久九九有精品国产23百花影院 | 国产欧美日韩精品a在线观看| 一线二线无人区乱码| 丰满的少妇邻居中文bd| 香蕉久久人人爽人人爽人人片av| а天堂中文官网| 永久免费无码成人网站| 成人a毛片视频免费看| 狠狠色狠狠色综合网| 美女内射毛片在线看免费人动物| 国产成人av免费网址| 国产亚洲日韩一区二区三区| 搡老熟女国产| 成在人线av无码免观看午夜网| 午夜电影网va内射| 亚洲色欲色欲www在线看| 少妇做爰免费视频了| 成人国产三级在线观看| 亚洲色欲在线播放一区| 国产精品无码一本二本三本色 | 天天躁日日躁狠狠躁视频2021| 国产精品交换| 日本妇人成熟免费中文字幕| 在线观看片免费视频无码| 国产成人精品优优av| 日产精品卡二卡三卡四卡乱码视频| 无码人妻专区免费视频| 亚洲爆乳少妇无码激情| 欧美巨大黑人极品精男| 4480yy私人精品国产| 亚洲最大成人av在线天堂网| 久久久久国产综合av天堂| 亚洲一码二码三码精华液| 欧美人伦禁忌dvd放荡欲情 | 特级无码毛片免费视频播放▽|