在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ROBO3 Antibody

  • 中文名稱:
    ROBO3兔多克隆抗體
  • 貨號:
    CSB-PA020056GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ROBO3
  • 別名:
    FLJ21044 antibody; HGPPS antibody; HGPS antibody; RB inhibiting gene 1 antibody; Rbig 1 antibody; Rbig1 antibody; Retinoblastoma inhibiting gene 1 antibody; Rig 1 antibody; Rig1 antibody; Robo 3 antibody; Robo3 antibody; Robo3 protein antibody; ROBO3_HUMAN antibody; Roundabout axon guidance receptor homolog 3 antibody; Roundabout homolog 3 antibody; Roundabout like protein 3 antibody; Roundabout, axon guidance receptor, homolog 3 (Drosophila) antibody; Roundabout-like protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human ROBO3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
  • 基因功能參考文獻:
    1. In our case, we found a novel homozygous mutation p.R842* (c.2524C>T) causing a premature stop codon which is a disease-making mutation. PMID: 27267957
    2. confirmed that ROBO3 increases with clinical grade and miR-383 expression is inversely correlated to that of ROBO3 PMID: 26070964
    3. human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330 PMID: 25882844
    4. We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations). PMID: 24969490
    5. Robo3.1A may prevent the Slit responsiveness by recruiting Robo1/2 into a late endosome- and lysosome-dependent degradation pathway. PMID: 24936616
    6. The novel ROBO3 mutation in this family may be among the most deleterious PMID: 21592015
    7. This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations PMID: 21510772
    8. Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis. PMID: 21850172
    9. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    10. identified mutations in the ROBO3 gene in patients affected with horizontal gaze palsy with progressive scoliosis (HGPPS);ROBO3 is required for hindbrain axon midline crossing PMID: 15105459
    11. The major clinical characteristics of patients with mutated ROBO3 were horizontal gaze palsy, progressive scoliosis, and brainstem malformations. PMID: 15824346
    12. Here we describe and compare two human Robo3 isoforms, Robo3A and Robo3B, which differ by the insertion of 26 amino acids at the N-terminus, and these forms appear to be evolutionary conserved PMID: 16226035
    13. Incidence of scoliosis in individuals harbouring heterozygous ROBO3 mutations may be greater than in the general population. PMID: 16525029
    14. No evidence for association between Gilles de la Tourette Syndrome and either the ROBO3 gene. Thus, this gene is unlikely to be the susceptibility genes contributing to GTS on 11q24. PMID: 17671968
    15. Four SNPs of ROBO3 showed associations with autism PMID: 18270976
    16. This study found five novel homozygous ROBO3 mutations (four missense mutations and one base deletion) distributed throughout the extracellular domain of the gene in consanguineous families with horizontal gaze palsy and progressive scoliosis. PMID: 18829051
    17. This is the second reported patient with synergistic convergence and the first associated with a documented pathologic genotype. PMID: 19041479
    18. mutations in the ROBO3 gene, which shares homology with roundabout genes important in axon guidance in developing Drosophila, zebrafish, and mouse. PMID: 15105459

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Gaze palsy, familial horizontal, with progressive scoliosis, 1 (HGPPS1)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, ROBO family
  • 數據庫鏈接:

    HGNC: 13433

    OMIM: 607313

    KEGG: hsa:64221

    STRING: 9606.ENSP00000380903

    UniGene: Hs.435621



主站蜘蛛池模板: 天天躁夜夜躁狠狠综合2020| 中文字幕一二三区波多野结衣 | 欧美精品九九久久久久久久久 | 国产精品日韩av在线播放| 色欲久久人妻内射| 精品亚洲成av人在线观看| 亚洲性猛交xxxx| 欧美黑人又粗又大高潮喷水| 日韩成人无码毛片一区二区| 草草网站影院白丝内射| 99精品视频在线观看免费| 亚洲男女羞羞无遮挡久久丫| 免费无码观看的av在线播放| 亚洲成aⅴ人片在线观| 国产精品美女久久久久久久久| 强伦人妻一区二区三区视频18| 日日噜噜大屁股熟妇| 国内极度色诱视频网站| 日产中文字幕在线观看| 香港经典a毛片免费观看hd| 亚洲成av 人片在线观看无码| 国产精品久久久久影院老司| 日日拍夜夜嗷嗷叫国产| 久久综合少妇11p| 欧美xxxx黑人又粗又长| 搡老熟女老女人一区二区| 国产亚洲视频在线播放香蕉| 青青草国产免费国产是公开| 92国产精品午夜福利免费| 香蕉久久一区二区三区啪啪| 亚洲成国产人片在线观看| 狠狠色丁香久久综合婷婷| 久久zyz资源站无码中文动漫| 久久久橹橹橹久久久久高清| 成人无遮挡裸免费视频在线观看| 四虎影视永久免费观看| 成人乱人伦视频在线观看| 国产精品自在线拍亚洲另类| 亚洲美女又黄又爽在线观看| 伊人久久综合成人网| 亚洲成av人片天堂网九九 |